Poland· PL-100337392
Depakine Chrono 500
A valproic acid product containing natrii valproas + acidum valproicum, registered in Poland by Delfarma Sp. z o.o.. The same ATC class is registered in 16 of our 19 countries.
Checked against URPL (Poland) on
Informational only — not a medical device.
Where it is registered
Valproic acid is registered in 16 of 19 countries.
Countries holding a registration under ATC N03AG01 (valproic acid), each read from that country’s own register.
- This record: Poland, from URPL (Poland)
- 9 of them publish a price we can compare per daily dose
Valproic acid · ATC N03AG01
16 / 19 countries
- Belgiumprice
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Germany
- Icelandprice
- Ireland
- Italyprice
- Japan
- Netherlands
- Norwayprice
- Polandprice
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of valproic acid costs, country by country.
Normalised to the WHO defined daily dose (1.5 g), so markets compare like for like.
- 1 market with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
Valproic acid · price per daily dose (1.5 g)
USD · FX 28 Sept 2026
- CH Switzerland$1.61
The record
At a glance
URPL (Poland)- Active substance
- Natrii valproas + Acidum valproicum
- Manufacturer
- Delfarma Sp. z o.o.
- Country
- Poland (PL)
- ATC code
- N03AG01
- ATC class
- Valproic acid
- Defined daily dose
- 1.5 g, O
- Reimbursed
- Not published by this register
- Source register
- URPL (Poland)
- Last checked
- September 27, 2026
Packs & prices · 1
- gtin05909991210328
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
391 interactions on record for valproic acid.
Graded by severity as the source publishes them — 9 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Valproic acid · interactions on record
391 records
- 9 severe
- 132 moderate
- 23 minor
- 189 info
Most severe, free to view
- Glycerol phenylbutyrateA16AX09severe
- BexaroteneL01XF03severe
- VorinostatL01XH01severe
- BexarotenL01XX25severe
38 more interactions with mechanism and management, from a commercially licensed source.
Sign in to check- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Valproic acid in 6 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- GermanyErgenyl ChronoSanofi-Aventis Deutschland Gmbh
- FinlandDeprakineParanova Oy
- SwitzerlandDepakine Chrono
- IrelandEpilim Chrono 200mg Prolonged Release TabletsSanofi-Aventis Ireland Limited T/A SANOFI
- SwedenErgenyl Retard 100 mg Depotgranulat i dospåseSanofi AB
- NorwayErgenyl chronosanofi-aventis (2)
Authorised across Europe · EMA
The same active substance is authorised in 26 EEA countries. Names it is sold under:
- Austria · Depakine Chrono Retard, Depakine Chronosphere
- Belgium · Depakine Chrono, Valproate Retard Eg
- Bulgaria · Депакин Хроно
- Cyprus · Depakine Chrono
- Czechia · Depakine Chrono, Valproat
- Germany · Ergenyl Chrono, Orfiril
- Estonia · Depakine Chrono
- Spain · Ácido Valproico Aurovitas, Depakine Crono
- Finland · Deprakine
- France · Depakine Chrono, Micropakine L.P.
- United Kingdom (Northern Ireland) · Alprolep 200mg Prolonged-Release Tablets, Alprolep 300mg Prolonged-Release Tablets
- Greece · Depakine Chrono, Depakine Chrono (Sphere)
- Croatia · Depakine Chrono
- Hungary · Depakine Chrono
- Ireland · Epilim Chrono, Epilim Chronosphere
- Italy · Acido Valproico E Sodio Valproato Eg, Acido Valproico E Sodio Valproato Ratiopharm
- Lithuania · Depakine Chrono, Depakine Chronosphere
- Luxembourg · Depakine Chrono, Valproate Retard Eg
- Latvia · Depakine Chrono
- Malta · Epilim Chrono
- Netherlands · Depakine Chrono, Depakine Chronosphere
- Portugal · Ácido Valpróico Aurovitas, Ácido Valpróico Generis
- Romania · Depakine Chrono
- Sweden · Ergenyl Retard
- Slovenia · Depakine Chrono
- Slovakia · Depakine Chrono, Valpro Chrono
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of URPL (Poland). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/f89a2a7f-b685-49cf-affc-75505702d149 GET /v1/drugs/f89a2a7f-b685-49cf-affc-75505702d149?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"form": "Tabletki powlekane o przedłużonym uwalnianiu",
"source": "urpl",
"strength": "333 mg + 145 mg",
"packaging": "05909991210328 ¦ Rp ¦ 106946\n30 tabl.",
"substance": "Natrii valproas 333 mg + Acidum valproicum 145 mg",
"common_name": "Natrii valproas + Acidum valproicum",
"pl_product_id": "100337392",
"pozwolenie_nr": "84/15",
"auth_procedure": "IR",
"authorisation_validity": "2030-02-23"
}See everything about valproic acid.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.