Ireland· IE-PA-PA0540/150/010
Epilim Chrono 200mg Prolonged Release Tablets
A valproic acid product containing sodium valproate + valproic acid, registered in Ireland by Sanofi-Aventis Ireland Limited T/A SANOFI. The same ATC class is registered in 16 of our 19 countries.
Checked against HPRA (Ireland) on
Informational only — not a medical device.
Where it is registered
Valproic acid is registered in 16 of 19 countries.
Countries holding a registration under ATC N03AG01 (valproic acid), each read from that country’s own register.
- This record: Ireland, from HPRA (Ireland)
- 9 of them publish a price we can compare per daily dose
Valproic acid · ATC N03AG01
16 / 19 countries
- Belgiumprice
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Germany
- Icelandprice
- Ireland
- Italyprice
- Japan
- Netherlands
- Norwayprice
- Polandprice
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of valproic acid costs, country by country.
Normalised to the WHO defined daily dose (1.5 g), so markets compare like for like.
- 1 market with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
Valproic acid · price per daily dose (1.5 g)
USD · FX 28 Sept 2026
- CH Switzerland$1.61
The record
At a glance
HPRA (Ireland)- Active substance
- Sodium valproate + Valproic acid
- Manufacturer
- Sanofi-Aventis Ireland Limited T/A SANOFI
- Country
- Ireland (IE)
- ATC code
- N03AG01
- ATC class
- Valproic acid
- Defined daily dose
- 1.5 g, O
- Reimbursed
- Not published by this register
- Source register
- HPRA (Ireland)
- Last checked
- September 28, 2026
Packs & prices · 1
- ie_pa_numberPA0540/150/010
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
391 interactions on record for valproic acid.
Graded by severity as the source publishes them — 9 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Valproic acid · interactions on record
391 records
- 9 severe
- 132 moderate
- 23 minor
- 189 info
Most severe, free to view
- Glycerol phenylbutyrateA16AX09severe
- BexaroteneL01XF03severe
- VorinostatL01XH01severe
- BexarotenL01XX25severe
38 more interactions with mechanism and management, from a commercially licensed source.
Sign in to check- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Valproic acid in 6 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- GermanyErgenyl ChronoSanofi-Aventis Deutschland Gmbh
- FinlandDeprakinesanofi-aventis Oy
- PolandDepakine Chrono 300Sanofi Sp. z o.o.
- SwitzerlandDepakine Chrono
- SwedenErgenyl Retard 100 mg Depotgranulat i dospåseSanofi AB
- NorwayErgenyl chronosanofi-aventis (2)
Authorised across Europe · EMA
The same active substance is authorised in 26 EEA countries. Names it is sold under:
- Austria · Depakine Chrono Retard, Depakine Chronosphere
- Belgium · Depakine Chrono, Valproate Retard Eg
- Bulgaria · Депакин Хроно
- Cyprus · Depakine Chrono
- Czechia · Depakine Chrono, Valproat
- Germany · Ergenyl Chrono, Orfiril
- Estonia · Depakine Chrono
- Spain · Ácido Valproico Aurovitas, Depakine Crono
- Finland · Deprakine
- France · Depakine Chrono, Micropakine L.P.
- United Kingdom (Northern Ireland) · Alprolep 200mg Prolonged-Release Tablets, Alprolep 300mg Prolonged-Release Tablets
- Greece · Depakine Chrono, Depakine Chrono (Sphere)
- Croatia · Depakine Chrono
- Hungary · Depakine Chrono
- Italy · Acido Valproico E Sodio Valproato Eg, Acido Valproico E Sodio Valproato Ratiopharm
- Lithuania · Depakine Chrono, Depakine Chronosphere
- Luxembourg · Depakine Chrono, Valproate Retard Eg
- Latvia · Depakine Chrono
- Malta · Epilim Chrono
- Netherlands · Depakine Chrono, Depakine Chronosphere
- Poland · Depakine Chrono 300, Depakine Chrono 500
- Portugal · Ácido Valpróico Aurovitas, Ácido Valpróico Generis
- Romania · Depakine Chrono
- Sweden · Ergenyl Retard
- Slovenia · Depakine Chrono
- Slovakia · Depakine Chrono, Valpro Chrono
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of HPRA (Ireland). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/468e945d-59c1-45f2-a953-a7ad209cfc2f GET /v1/drugs/468e945d-59c1-45f2-a953-a7ad209cfc2f?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"form": "Prolonged-release tablet",
"routes": [
"Oral use"
],
"source": "hpra",
"atc_all": [
"N03AG",
"N03AG01"
],
"strength": null,
"pa_number": "PA0540/150/010",
"substances": [
"Sodium valproate",
"Valproic acid"
],
"legal_basis": "Full application (Article 8(3) of Directive No 2001/83/EC)",
"market_info": "Marketed",
"authorised_at": "24/08/1992",
"dispensing_status": "Product subject to prescription which may be renewed (B)",
"registration_status": "AU",
"supply_legal_status": "Supply through pharmacies only",
"interchangeable_code": null
}See everything about valproic acid.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.