United Kingdom· GB-APID-42998911000001106

Tapentadol 250mg modified-release tablets

A tapentadol product containing tapentadol, registered in United Kingdom by Aspire Pharma Ltd. The same ATC class is registered in 17 of our 19 countries.

ATC N02AX06

Checked against NHS dm+d (United Kingdom) on September 13, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about tapentadolAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Tapentadol is registered in 17 of 19 countries.

Countries holding a registration under ATC N02AX06 (tapentadol), each read from that country’s own register.

This record: United Kingdom, from NHS dm+d (United Kingdom)
10 of them publish a price we can compare per daily dose

Search tapentadol products by name

Tapentadol · ATC N02AX06

17 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Germany
Icelandprice
Ireland
Italyprice
Netherlands
Norwayprice
Polandprice
Spainprice
Sweden
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of tapentadol costs, country by country.

Normalised to the WHO defined daily dose (0.4 g), the median price runs from $2.14 in Italy to $6.62 in Switzerland — a ×3.1 gap.

3 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Tapentadol · price per daily dose (0.4 g)

USD · FX 28 Sept 2026

CH Switzerland$6.62
ES Spain$3.34
IT Italy$2.14

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

NHS dm+d (United Kingdom)

Active substance: Tapentadol
Manufacturer: Aspire Pharma Ltd
Country: United Kingdom (GB)
ATC code: N02AX06
ATC class: Tapentadol
Defined daily dose: 0.4 g, O
Reimbursed: Not published by this register
Source register: NHS dm+d (United Kingdom)
Last checked: September 13, 2026

Packs & prices · 1

gtin
5060209733241

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

184 interactions on record for tapentadol.

Graded by severity as the source publishes them — 30 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check tapentadol against other medicines How interaction checks work

Tapentadol · interactions on record

184 records

30 severe
130 moderate

Most severe, free to view

OndansetronA04AA01severe
GranisetronA04AA02severe
DolasetronA04AA04severe
PalonosetronA04AA05severe

24 more interactions with mechanism and management, from a commercially licensed source.

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Tapentadol in 15 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All tapentadol products

Authorised across Europe · EMA

The same active substance is authorised in 24 EEA countries. Names it is sold under:

Austria · Palexia, Palexia Retard
Belgium · Palexia, Palexia Retard
Cyprus · Dolten, Dolten Retard
Czechia · Apeneta, Dolupren
Germany · Palexia, Palexia Akutschmerz
Denmark · Palexia, Palexia Depot
Estonia · Tapemed Retard
Spain · Palexia, Palexia Retard
Greece · Dolupren, Dolupren Ir
Croatia · Apeneta, Dolten
Hungary · Adoben
Ireland · Apeneta, Palexia
Iceland · Tapentadol Stada
Italy · Palexia, Taboxea
Luxembourg · Palexia, Palexia Retard
Malta · Dolten, Dolten Retard
Netherlands · Palexia, Palexia Retard
Norway · Palexia, Palexia Depot
Poland · Adoben, Binatta
Portugal · Ationdo, Palexia
Romania · Dolten
Sweden · Palexia, Palexia Depot
Slovenia · Apeneta, Palexia
Slovakia · Apeneta, Dolten

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of NHS dm+d (United Kingdom). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/e8cf58c6-3e7f-41ac-a50c-1b53807450bc
GET /v1/drugs/e8cf58c6-3e7f-41ac-a50c-1b53807450bc?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "apid": "42998911000001106",
  "desc": "Tapentadol 250mg modified-release tablets (Aspire Pharma Ltd)",
  "form": "Modified-release tablet",
  "vpid": "18672111000001109",
  "source": "dmd",
  "vtm_id": "777675005",
  "strength": "250 mg",
  "substance": "Tapentadol",
  "ingredient": "Tapentadol",
  "supplier_code": "16666911000001109"
}

API reference MCP server Plans

See everything about tapentadol.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it free Open in the console