Ireland· IE-PA-PA2242/012/008
Palexia SR 250 mg prolonged-release tablets
A tapentadol product containing tapentadol hydrochloride, registered in Ireland by Grunenthal Pharma Limited.. The same ATC class is registered in 17 of our 19 countries.
Checked against HPRA (Ireland) on
Informational only — not a medical device.
Where it is registered
Tapentadol is registered in 17 of 19 countries.
Countries holding a registration under ATC N02AX06 (tapentadol), each read from that country’s own register.
- This record: Ireland, from HPRA (Ireland)
- 10 of them publish a price we can compare per daily dose
Tapentadol · ATC N02AX06
17 / 19 countries
- Belgiumprice
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Germany
- Icelandprice
- Ireland
- Italyprice
- Netherlands
- Norwayprice
- Polandprice
- Spainprice
- Sweden
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of tapentadol costs, country by country.
Normalised to the WHO defined daily dose (0.4 g), the median price runs from $2.14 in Italy to $6.62 in Switzerland — a ×3.1 gap.
- 3 markets with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
Tapentadol · price per daily dose (0.4 g)
USD · FX 28 Sept 2026
- CH Switzerland$6.62
- ES Spain$3.34
- IT Italy$2.14
The record
At a glance
HPRA (Ireland)- Active substance
- Tapentadol hydrochloride
- Manufacturer
- Grunenthal Pharma Limited.
- Country
- Ireland (IE)
- ATC code
- N02AX06
- ATC class
- Tapentadol
- Defined daily dose
- 0.4 g, O
- Reimbursed
- Not published by this register
- Source register
- HPRA (Ireland)
- Last checked
- September 28, 2026
Packs & prices · 1
- ie_pa_numberPA2242/012/008
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
184 interactions on record for tapentadol.
Graded by severity as the source publishes them — 30 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Tapentadol · interactions on record
184 records
- 30 severe
- 130 moderate
Most severe, free to view
- OndansetronA04AA01severe
- GranisetronA04AA02severe
- DolasetronA04AA04severe
- PalonosetronA04AA05severe
24 more interactions with mechanism and management, from a commercially licensed source.
Sign in to check- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Tapentadol in 15 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- CzechiaMABINOVANSandoz s.r.o., Praha
- United KingdomAtiondo SR 250mg tabletsGrunenthal Ltd
- SpainPALEXIA RETARD 250 mg COMPRIMIDOS DE LIBERACION PROLONGADAGrünenthal Pharma S.A.
- SwedenPalexia Depot 250 mg DepottablettGrünenthal GmbH
- NetherlandsPalexia Retard 250 mg tabletten met verlengde afgifteGrünenthal B.V.
- PolandAdobenKrka, d.d., Novo mesto
- BelgiumPalexia Retard 250 mgGrunenthal
- ItalyPALEXIAGRUNENTHAL ITALIA S.R.L.
Authorised across Europe · EMA
The same active substance is authorised in 24 EEA countries. Names it is sold under:
- Austria · Palexia, Palexia Retard
- Belgium · Palexia, Palexia Retard
- Cyprus · Dolten, Dolten Retard
- Czechia · Apeneta, Dolupren
- Germany · Palexia, Palexia Akutschmerz
- Denmark · Palexia, Palexia Depot
- Estonia · Tapemed Retard
- Spain · Palexia, Palexia Retard
- United Kingdom (Northern Ireland) · Ationdo, Ationdo Sr
- Greece · Dolupren, Dolupren Ir
- Croatia · Apeneta, Dolten
- Hungary · Adoben
- Iceland · Tapentadol Stada
- Italy · Palexia, Taboxea
- Luxembourg · Palexia, Palexia Retard
- Malta · Dolten, Dolten Retard
- Netherlands · Palexia, Palexia Retard
- Norway · Palexia, Palexia Depot
- Poland · Adoben, Binatta
- Portugal · Ationdo, Palexia
- Romania · Dolten
- Sweden · Palexia, Palexia Depot
- Slovenia · Apeneta, Palexia
- Slovakia · Apeneta, Dolten
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of HPRA (Ireland). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/2e33b598-c4dc-4518-96f9-baf377886dfe GET /v1/drugs/2e33b598-c4dc-4518-96f9-baf377886dfe?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"form": "Prolonged-release tablet",
"routes": [
"Oral use"
],
"source": "hpra",
"atc_all": [
"N02AX",
"N02AX06"
],
"strength": null,
"pa_number": "PA2242/012/008",
"substances": [
"Tapentadol hydrochloride"
],
"legal_basis": "Full application (Article 8(3) of Directive No 2001/83/EC)",
"market_info": "Marketed",
"authorised_at": "21/12/2010",
"dispensing_status": "Product subject to prescription which may not be renewed (A)",
"registration_status": "AU",
"supply_legal_status": "Supply through pharmacies only",
"interchangeable_code": "IC0167-130-024"
}See everything about tapentadol.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.