United States· US:64281-100_52a662b1-6841-8e8e-e063-6394a90a51e6
Provocholine
A methacholine product containing methacholine chloride, registered in United States by Methapharm Inc.. The same ATC class is registered in 8 of our 19 countries.
Checked against FDA National Drug Code directory (United States) on
Informational only — not a medical device.
Where it is registered
Methacholine is registered in 8 of 19 countries.
Countries holding a registration under ATC V04CX03 (methacholine), each read from that country’s own register.
- This record: United States, from FDA National Drug Code directory (United States)
- 2 of them publish a price we can compare per daily dose
Methacholine · ATC V04CX03
8 / 19 countries
- Denmark
- Germany
- Ireland
- Japan
- Netherlands
- Norwayprice
- United Kingdom
- United Statesprice
The record
At a glance
FDA National Drug Code directory (United States)- Active substance
- methacholine chloride
- Manufacturer
- Methapharm Inc.
- Country
- United States (US)
- ATC code
- V04CX03
- ATC class
- Methacholine
- Reimbursed
- Not published by this register
- Source register
- FDA National Drug Code directory (United States)
- Last checked
- June 3, 2026
Packs & prices · 1
- ndc1164281100066 VIAL, GLASS in 1 BOX (64281-100-06) / 100 mg in 1 VIAL, GLASS (64281-100-00)
Regulatory notes
Interactions
24 interactions on record for methacholine.
Graded by severity as the source publishes them — 18 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Methacholine · interactions on record
24 records
- 18 severe
- 6 moderate
Most severe, free to view
- PindololC07AA03severe
- PropranololC07AA05severe
- TimololC07AA06severe
- SotalolC07AA07severe
- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Methacholine in 10 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- NorwayMetakolin SASykehusapotekene HF
- CanadaMETHACHOLINE OMEGAOMEGA LABORATORIES LIMITED
- Japanメタコリン塩化物三和化学研究所
- United KingdomProvocholine 100mg powder for nebuliser solution vialsMWK Healthcare Ltd
- IrelandMethacholine chloride 100 mg Powder for nebuliser solutionMethapharm Limited
- NetherlandsProvocholine 100 mg poeder voor verneveloplossingMethapharm Limited
- SpainPROVOCHOLINE 100 MG POLVO PARA SOLUCIÓN PARA INHALACION POR NEBULIZADORDiater Laboratorio De Diagnostico Y Aplicaciones Terapeuticas S.A.
- SwedenProvocholine 100 mg Pulver till lösning för nebulisatorMETHPHARMA LTD
Authorised across Europe · EMA
The same active substance is authorised in 9 EEA countries. Names it is sold under:
- Germany · Provokit
- Denmark · Provocholine
- Spain · Provocholine
- France · Chlorure De Methacholine Panpharma
- Ireland · Methacholine Chloride Methapharm
- Italy · Metacolina Lofarma
- Netherlands · Provocholine
- Norway · Provocholine
- Sweden · Provocholine
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/dd5b1aba-47f4-4770-8d4a-90af6ff78124 GET /v1/drugs/dd5b1aba-47f4-4770-8d4a-90af6ff78124?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"unii": {
"unii": "0W5ETF9M2K",
"rxcui": "40165",
"inchikey": "JHPHVAVFUYTVCL-UHFFFAOYSA-M",
"display_name": "METHACHOLINE CHLORIDE",
"substance_type": "chemical",
"ingredient_type": "INGREDIENT SUBSTANCE"
},
"route": "RESPIRATORY (INHALATION)",
"spl_meta": {
"e8983096-65e6-41f2-8b6f-bbf0a7227307": {
"match": "brand_token",
"title": "PROVOCHOLINE (METHACHOLINE CHLORIDE) POWDER, FOR SOLUTION PROVOCHOLINE INHALATION SOLUTION (METHACHOLINE CHLORIDE INHALATION SOLUTION) SOLUTION PROVOCHOLINE INHALATION SOLUTION (METHACHOLINE CHLORIDE INHALATION SOLUTION) KIT [METHAPHARM INC.]",
"spl_version": "27",
"published_date": "2026-05-27"
}
},
"productid": "64281-100_52a662b1-6841-8e8e-e063-6394a90a51e6",
"productndc": "64281-100",
"dosage_form": "POWDER, FOR SOLUTION",
"orange_book": {
"appl_no": "019193",
"products": [
{
"rs": true,
"rld": true,
"te_code": null,
"strength": "100MG/VIAL",
"product_no": "001",
"approval_date": "Oct 31, 1986"
},
{
"rs": false,
"rld": true,
"te_code": null,
"strength": "1600MG/VIAL",
"product_no": "002",
"approval_date": "Aug 29, 2016"
}
],
"appl_type": "N"
},
"dea_schedule": null,
"product_type": "HUMAN PRESCRIPTION DRUG",
"substance_name": "METHACHOLINE CHLORIDE",
"proprietary_name": "Provocholine",
"active_ingred_unit": "mg/100mg",
"application_number": "NDA019193",
"marketing_category": "NDA",
"nonproprietary_name": "methacholine chloride",
"start_marketing_date": "20130327",
"active_numerator_strength": "100"
}See everything about methacholine.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.