Canada· CA-DIN-02551918
MAR-LEFLUNOMIDE
A leflunomide product containing leflunomide, registered in Canada by MARCAN PHARMACEUTICALS INC. The same ATC class is registered in 15 of our 19 countries.
Checked against Health Canada Drug Product Database (Canada) on
Informational only — not a medical device.
Where it is registered
Leflunomide is registered in 15 of 19 countries.
Countries holding a registration under ATC L04AK01 (leflunomide), each read from that country’s own register.
- This record: Canada, from Health Canada Drug Product Database (Canada)
- 9 of them publish a price we can compare per daily dose
Leflunomide · ATC L04AK01
15 / 19 countries
- Belgiumprice
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Germany
- Icelandprice
- Italyprice
- Japan
- Netherlands
- Norwayprice
- Polandprice
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of leflunomide costs, country by country.
Normalised to the WHO defined daily dose (20 mg), the median price runs from $0.47 in United States to $2.13 in Italy — a ×4.5 gap.
- 3 markets with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
- US figures are pharmacy acquisition cost (CMS NADAC), not retail
Leflunomide · price per daily dose (20 mg)
USD · FX 28 Sept 2026
- IT Italy$2.13
- CH Switzerland$1.48
- US United States$0.47 (acquisition cost)
The record
At a glance
Health Canada Drug Product Database (Canada)- Active substance
- LEFLUNOMIDE
- Manufacturer
- MARCAN PHARMACEUTICALS INC
- Country
- Canada (CA)
- ATC code
- L04AK01
- ATC class
- Leflunomide
- Defined daily dose
- 20 mg, O
- Reimbursed
- Not published by this register
- Source register
- Health Canada Drug Product Database (Canada)
- Last checked
- October 1, 2026
Packs & prices · 0
No packs listed by the register for this record.
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
805 interactions on record for leflunomide.
Graded by severity as the source publishes them — 537 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Leflunomide · interactions on record
805 records
- 537 severe
- 47 moderate
- 7 minor
- 214 info
Most severe, free to view
- ClotrimazoleA01AB18severe
- Chenodeoxycholic acidA05AA01severe
- PrednisoloneA07EA01severe
- HydrocortisoneA07EA02severe
- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Leflunomide in 16 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- United KingdomArava 10mg tabletsWaymade Healthcare Plc
- United StatesleflunomideHeritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
- SwitzerlandLeflunomid-Mepha
- SpainLEFLUNOMIDA TILLOMED 10 MG COMPRIMIDOS EFGLaboratorios Tillomed Spain S.L.
- NetherlandsLeflunomide Tillomed 10 mg, tablettenTillomed Pharma GmbH
- NorwayLeflunomide zentivaZentiva
- CzechiaARAVASanofi-Aventis Deutschland GmbH, Frankfurt am Main
- BelgiumArava 10 mgSanofi-Aventis Deutschland
Authorised across Europe · EMA
The same active substance is authorised in 27 EEA countries. Names it is sold under:
- Austria · Leflunomid Stada
- Belgium · Leflunomid Sandoz, Leflunomide Ab
- Bulgaria · Багеда
- Cyprus · Arotan
- Czechia · Leflon, Leflugen
- Germany · Leflon, Leflunomid 1 A Pharma
- Denmark · Leflunomid, Leflunomid "egis"
- Estonia · Leflunomide Elvim
- Spain · Lefluartil, Leflunomida Aurovitas
- Finland · Leflunomide Orion, Leflunomide Stada
- France · Leflunomide Arrow, Leflunomide Biogaran
- United Kingdom (Northern Ireland) · Leflunomide Aspire Pharma, Leflunomide Milpharm
- Greece · Lefid, Lefluonia
- Hungary · Leflunomid Sandoz
- Ireland · Leflunomide Aspire Pharma (Malta)
- Iceland · Arava, Leflunomide Medac
- Italy · Leflunomide Aurobindo, Leflunomide Mylan
- Liechtenstein · Arava, Leflunomide Medac
- Lithuania · Leflunomide Elvim, Leflunomide Sandoz
- Latvia · Leflunomide Elvim, Leflunomide Sandoz
- Malta · Leflunomide Normon
- Netherlands · Leflunomide Aurobindo, Leflunomide Cf
- Norway · Arava, Leflunomide Medac
- Poland · Leflunomid Bluefish, Leflunomid Egis
- Portugal · Leflunomida Farmoz, Leflunomida Generis
- Romania · Leflon, Leflunomidă Arena
- Sweden · Leflunomid Bluefish
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of Health Canada Drug Product Database (Canada). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/ca3503f3-882e-4bde-bf85-6486e8fd6b11 GET /v1/drugs/ca3503f3-882e-4bde-bf85-6486e8fd6b11?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"din": "02551918",
"form": "TABLET",
"class": "Human",
"routes": [
"ORAL"
],
"source": "health_canada_dpd",
"status": "MARKETED",
"atc_raw": "L04AK01",
"schedule": [
"Prescription"
],
"drug_code": "104061",
"strengths": [
"10 MG"
],
"ahfs_class": null,
"substances": [
"LEFLUNOMIDE"
],
"product_categorization": null
}See everything about leflunomide.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.