United States· US:64281-100_552ab9cb-08af-1139-e063-6294a90a93f0
Provocholine
A methacholine product containing methacholine chloride, registered in United States by Methapharm Inc.. The same ATC class is registered in 8 of our 19 countries.
Checked against FDA National Drug Code directory (United States) on
Informational only — not a medical device.
Where it is registered
Methacholine is registered in 8 of 19 countries.
Countries holding a registration under ATC V04CX03 (methacholine), each read from that country’s own register.
- This record: United States, from FDA National Drug Code directory (United States)
- 2 of them publish a price we can compare per daily dose
Methacholine · ATC V04CX03
8 / 19 countries
- Denmark
- Germany
- Ireland
- Japan
- Netherlands
- Norwayprice
- United Kingdom
- United Statesprice
The record
At a glance
FDA National Drug Code directory (United States)- Active substance
- METHACHOLINE CHLORIDE
- Manufacturer
- Methapharm Inc.
- Country
- United States (US)
- ATC code
- V04CX03
- ATC class
- Methacholine
- Reimbursed
- Not published by this register
- Source register
- FDA National Drug Code directory (United States)
- Last checked
- August 23, 2026
Packs & prices · 1
- ndc1164281-100-06
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
24 interactions on record for methacholine.
Graded by severity as the source publishes them — 18 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Methacholine · interactions on record
24 records
- 18 severe
- 6 moderate
Most severe, free to view
- PindololC07AA03severe
- PropranololC07AA05severe
- TimololC07AA06severe
- SotalolC07AA07severe
- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Methacholine in 10 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- NorwayMetakolin SASykehusapotekene HF
- CanadaMETHACHOLINE OMEGAOMEGA LABORATORIES LIMITED
- Japanメタコリン塩化物三和化学研究所
- United KingdomProvocholine 100mg powder for nebuliser solution vialsMWK Healthcare Ltd
- IrelandMethacholine chloride 100 mg Powder for nebuliser solutionMethapharm Limited
- NetherlandsProvocholine 100 mg poeder voor verneveloplossingMethapharm Limited
- SpainPROVOCHOLINE 100 MG POLVO PARA SOLUCIÓN PARA INHALACION POR NEBULIZADORDiater Laboratorio De Diagnostico Y Aplicaciones Terapeuticas S.A.
- SwedenProvocholine 100 mg Pulver till lösning för nebulisatorMETHPHARMA LTD
Authorised across Europe · EMA
The same active substance is authorised in 9 EEA countries. Names it is sold under:
- Germany · Provokit
- Denmark · Provocholine
- Spain · Provocholine
- France · Chlorure De Methacholine Panpharma
- Ireland · Methacholine Chloride Methapharm
- Italy · Metacolina Lofarma
- Netherlands · Provocholine
- Norway · Provocholine
- Sweden · Provocholine
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/bdf31a89-ae8c-458f-8ea0-c1fc1c7ec0af GET /v1/drugs/bdf31a89-ae8c-458f-8ea0-c1fc1c7ec0af?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"route": "RESPIRATORY (INHALATION)",
"source": "ndc",
"strength": "100",
"substance": "METHACHOLINE CHLORIDE",
"productndc": "64281-100",
"dosage_form": "POWDER, FOR SOLUTION",
"dea_schedule": null,
"strength_unit": "mg/100mg",
"application_number": "NDA019193",
"marketing_category": "NDA"
}See everything about methacholine.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.