United States· US:70301-1001_7a2aae40-1f27-460f-bc3b-7227ce031d4e

Rayaldee

A calcifediol product containing calcifediol, registered in United States by OPKO Pharmaceuticals LLC. The same ATC class is registered in 6 of our 19 countries.

ATC H05BX05

Checked against FDA National Drug Code directory (United States) on September 27, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about calcifediolAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Calcifediol is registered in 6 of 19 countries.

Countries holding a registration under ATC H05BX05 (calcifediol), each read from that country’s own register.

This record: United States, from FDA National Drug Code directory (United States)
2 of them publish a price we can compare per daily dose

Search calcifediol products by name

Calcifediol · ATC H05BX05

6 / 19 countries

Denmark
Germany
Netherlands
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of calcifediol costs, country by country.

Normalised to the WHO defined daily dose (30 mcg), the median price runs from $0.13 in Spain to $4.51 in Switzerland — a ×34 gap.

2 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Calcifediol · price per daily dose (30 mcg)

USD · FX 28 Sept 2026

CH Switzerland$4.51
ES Spain$0.13

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

FDA National Drug Code directory (United States)

Active substance: CALCIFEDIOL
Manufacturer: OPKO Pharmaceuticals LLC
Country: United States (US)
ATC code: H05BX05
ATC class: Calcifediol
Defined daily dose: 30 mcg, O
Reimbursed: Not published by this register
Source register: FDA National Drug Code directory (United States)
Last checked: September 27, 2026

Packs & prices · 3

ndc11
70301-1001-2
ndc11
70301-1001-1
ndc11
70301-1001-3

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

68 interactions on record for calcifediol.

Graded by severity as the source publishes them — 10 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check calcifediol against other medicines How interaction checks work

Calcifediol · interactions on record

68 records

10 severe
57 moderate
1 minor

Most severe, free to view

ErgocalciferolA11CC01severe
DihydrotachysterolA11CC02severe
CalcitriolA11CC04severe
ColecalciferolA11CC05severe

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Calcifediol in 13 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All calcifediol products

Authorised across Europe · EMA

The same active substance is authorised in 27 EEA countries. Names it is sold under:

Austria · Hidroferol
Belgium · Dédrogyl, Defediol
Bulgaria · Хидроферол
Czechia · Uperold
Germany · Dedrogyl, Rayaldee
Denmark · Defevix, Rayaldee
Estonia · Defevix, Hidrosun
Spain · Calcifediol Normogen, Calcifediol Normon
Finland · Defevix
France · Calcifediol Desma, Calcifediol Gerda
United Kingdom (Northern Ireland) · Domnisol
Greece · D Ready, Hidroferol
Croatia · Defevix, Tryde
Hungary · Defevix
Ireland · Calcifediol Faes, Dnord
Italy · Didrogyl, Hercal
Lithuania · Calcifediol Faes, Defevix
Luxembourg · Defediol, Hidroferol Hebdomadaire
Latvia · Defevix
Netherlands · Dediol Wekelijks, Hidroferol
Norway · Defevix, Hidrosun
Poland · Calfos, Devisol-25
Portugal · Dedrogyl, Dvit
Romania · Hidroferol
Sweden · Defevix, Rayaldee
Slovenia · Defevix, Kalcifediol Faes
Slovakia · Defevix

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/6167fbf4-9054-45be-9726-89892736c582
GET /v1/drugs/6167fbf4-9054-45be-9726-89892736c582?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "route": "ORAL",
  "source": "ndc",
  "strength": "30",
  "substance": "CALCIFEDIOL",
  "productndc": "70301-1001",
  "dosage_form": "CAPSULE, EXTENDED RELEASE",
  "dea_schedule": null,
  "strength_unit": "ug/1",
  "application_number": "NDA208010",
  "marketing_category": "NDA"
}

API reference MCP server Plans

See everything about calcifediol.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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