Netherlands· NL-fb8ef5d07bc7

Rayaldee 30 microgram, zachte capsule met verlengde afgifte

A calcifediol product containing calcifediol 1-water, registered in Netherlands by Vifor Fresenius Medical Care Renal Pharma France. The same ATC class is registered in 6 of our 19 countries.

ATC H05BX05

Checked against CBG-MEB (Netherlands) on September 29, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about calcifediol 1-waterAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Calcifediol is registered in 6 of 19 countries.

Countries holding a registration under ATC H05BX05 (calcifediol), each read from that country’s own register.

This record: Netherlands, from CBG-MEB (Netherlands)
2 of them publish a price we can compare per daily dose

Search calcifediol products by name

Calcifediol · ATC H05BX05

6 / 19 countries

Denmark
Germany
Netherlands
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of calcifediol costs, country by country.

Normalised to the WHO defined daily dose (30 mcg), the median price runs from $0.13 in Spain to $4.51 in Switzerland — a ×34 gap.

2 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Calcifediol · price per daily dose (30 mcg)

USD · FX 28 Sept 2026

CH Switzerland$4.51
ES Spain$0.13

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

CBG-MEB (Netherlands)

Active substance: CALCIFEDIOL 1-WATER
Manufacturer: Vifor Fresenius Medical Care Renal Pharma France
Country: Netherlands (NL)
ATC code: H05BX05
ATC class: Calcifediol
Defined daily dose: 30 mcg, O
Reimbursed: Not published by this register
Source register: CBG-MEB (Netherlands)
Last checked: September 29, 2026

Packs & prices · 1

cbg_meb_id
124799

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

68 interactions on record for calcifediol.

Graded by severity as the source publishes them — 10 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check calcifediol against other medicines How interaction checks work

Calcifediol · interactions on record

68 records

10 severe
57 moderate
1 minor

Most severe, free to view

ErgocalciferolA11CC01severe
DihydrotachysterolA11CC02severe
CalcitriolA11CC04severe
ColecalciferolA11CC05severe

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Calcifediol in 13 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All calcifediol products

Authorised across Europe · EMA

The same active substance is authorised in 26 EEA countries. Names it is sold under:

Austria · Hidroferol
Belgium · Dédrogyl, Defediol
Bulgaria · Хидроферол
Czechia · Uperold
Germany · Dedrogyl, Rayaldee
Denmark · Defevix, Rayaldee
Estonia · Defevix, Hidrosun
Spain · Calcifediol Normogen, Calcifediol Normon
Finland · Defevix
France · Calcifediol Desma, Calcifediol Gerda
United Kingdom (Northern Ireland) · Domnisol
Greece · D Ready, Hidroferol
Croatia · Defevix, Tryde
Hungary · Defevix
Ireland · Calcifediol Faes, Dnord
Italy · Didrogyl, Hercal
Lithuania · Calcifediol Faes, Defevix
Luxembourg · Defediol, Hidroferol Hebdomadaire
Latvia · Defevix
Norway · Defevix, Hidrosun
Poland · Calfos, Devisol-25
Portugal · Dedrogyl, Dvit
Romania · Hidroferol
Sweden · Defevix, Rayaldee
Slovenia · Defevix, Kalcifediol Faes
Slovakia · Defevix

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/c1bd0563-7ba8-48d0-a958-c215779cf2f1
GET /v1/drugs/c1bd0563-7ba8-48d0-a958-c215779cf2f1?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Capsule met verlengde afgifte, zacht",
  "route": "Oraal gebruik",
  "soort": "RVG",
  "source": "cbg_meb",
  "smpc_url": "https://www.geneesmiddeleninformatiebank.nl/smpc/h124799_smpc.pdf",
  "strength": null,
  "atc_label": "Calcifediol",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/rvg124799",
  "excipients": [
    "BRILJANTBLAUW FCF (E 133)",
    "BUTYLHYDROXYTOLUEEN (E 321)",
    "CARRAGEENAN (E 407)",
    "DINATRIUMWATERSTOFFOSFAAT 0-WATER (E 339)",
    "ETHANOL",
    "GLYCEROLMONOSTEARAAT 40-55 (E 471)",
    "HYPROMELLOSE (E 464)",
    "HYPROMELLOSE 2208 (Release controlling polymer), K100M (E 464)",
    "LAUROYLMACROGOLGLYCERIDEN",
    "MAÏSZETMEEL, GEMODIFICEERD",
    "PARAFFINE, HARD (E 905)",
    "PARAFFINE, VLOEIBAAR (E905)",
    "PROPYLEENGLYCOL (E 1520)",
    "SORBITOL VLOEIBAAR, GEDEELTELIJK GEDEHYDRATEERD",
    "TITAANDIOXIDE (E 171)",
    "TITAANDIOXIDE (E 171)",
    "TRIGLYCERIDEN MIDDELLANGE KETEN",
    "WATER, GEZUIVERD",
    "WITTE INKT"
  ],
  "substances": [
    "CALCIFEDIOL 1-WATER"
  ],
  "leaflet_url": "https://www.geneesmiddeleninformatiebank.nl/bijsluiters/h124799.pdf",
  "authorised_at": "2020/09/22",
  "procedure_number": "DE/H/5590/001",
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "124799",
  "additional_monitoring": "N"
}

API reference MCP server Plans

See everything about calcifediol.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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