Ireland· IE-PA-PA23142/005/001

Methotrexate 10 mg tablets

A methotrexate product containing methotrexate, registered in Ireland by Aspire Pharma (Malta) Limited. The same ATC class is registered in 15 of our 19 countries.

ATC L04AX03

Checked against HPRA (Ireland) on September 28, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about methotrexateAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Methotrexate is registered in 15 of 19 countries.

Countries holding a registration under ATC L04AX03 (methotrexate), each read from that country’s own register.

This record: Ireland, from HPRA (Ireland)
9 of them publish a price we can compare per daily dose

Search methotrexate products by name

Methotrexate · ATC L04AX03

15 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Germany
Icelandprice
Ireland
Italyprice
Netherlands
Norwayprice
Polandprice
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of methotrexate costs, country by country.

Normalised to the WHO defined daily dose (2.5 mg), the median price runs from $0.16 in United States to $5.98 in Switzerland — a ×38 gap.

3 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown
US figures are pharmacy acquisition cost (CMS NADAC), not retail

Open the full comparison — free account Drug prices for market access

Methotrexate · price per daily dose (2.5 mg)

USD · FX 28 Sept 2026

CH Switzerland$5.98
IT Italy$0.20
US United States$0.16 (acquisition cost)

Median listed price per WHO defined daily dose, in each market that publishes a price. US = pharmacy acquisition cost (CMS NADAC), not a retail price. Open the full comparison

The record

At a glance

HPRA (Ireland)

Active substance: Methotrexate
Manufacturer: Aspire Pharma (Malta) Limited
Country: Ireland (IE)
ATC code: L04AX03
ATC class: Methotrexate
Defined daily dose: 2.5 mg, O
Reimbursed: Not published by this register
Source register: HPRA (Ireland)
Last checked: September 28, 2026

Packs & prices · 1

ie_pa_number
PA23142/005/001

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

929 interactions on record for methotrexate.

Graded by severity as the source publishes them — 107 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check methotrexate against other medicines How interaction checks work

Methotrexate · interactions on record

929 records

107 severe
466 moderate
17 minor
309 info

Most severe, free to view

OmeprazoleA02BC01severe
PantoprazoleA02BC02severe
LansoprazoleA02BC03severe
RabeprazoleA02BC04severe

30 more interactions with mechanism and management, from a commercially licensed source.

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Methotrexate in 17 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All methotrexate products

Authorised across Europe · EMA

The same active substance is authorised in 30 EEA countries. Names it is sold under:

Austria · Ebetrexat, Methofill
Belgium · Basitrin, Emthexate
Bulgaria · Ebetrexat, Инжексат
Cyprus · Injexate, Methotrexate Accord
Czechia · Foxiemo, Injexate
Germany · Lantarel, Lantarel Fs
Denmark · Ebetrex, Emthexate
Estonia · Ebetrex, Metex
Spain · Bertanel, Imeth
Finland · Ebetrex, Injexate
France · Imenor, Imeth
United Kingdom (Northern Ireland) · Ebetrex, Injexate
Greece · Methobion, Methotrexate Pfizer
Croatia · Ebetrexat, Methofill
Hungary · Ebetrexat, Methofill
Iceland · Jylamvo, Methotrexat Ebewe
Italy · Afslamet, Immutrex
Liechtenstein · Jylamvo, Nordimet
Lithuania · Ebetrexat, Metex
Luxembourg · Emthexate, Emthexate Teva Pharma
Latvia · Ebetrex, Metex
Malta · Methotrexate Aspire Pharma (Malta)
Netherlands · Basitrin, Ebetrex
Norway · Ebetrex, Jylamvo
Poland · Ebetrexat, Metex
Portugal · Fauldexato, Ledertrexato
Romania · Methotrexat Ebewe, Metorthrit
Sweden · Ebetrex, Injexate
Slovenia · Methofill, Metoject
Slovakia · Foxiemo, Injexate

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of HPRA (Ireland). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/514c5c4d-e16d-4849-8405-d6cedf540423
GET /v1/drugs/514c5c4d-e16d-4849-8405-d6cedf540423?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Tablet",
  "routes": [
    "Oral use"
  ],
  "source": "hpra",
  "atc_all": [
    "L04AX",
    "L04AX03"
  ],
  "strength": null,
  "pa_number": "PA23142/005/001",
  "substances": [
    "Methotrexate"
  ],
  "legal_basis": "Generic application (Article 10(1) of Directive No 2001/83/EC)",
  "market_info": "Not marketed",
  "authorised_at": "21/03/2011",
  "dispensing_status": "Product subject to prescription which may not be renewed (A)",
  "registration_status": "AU",
  "supply_legal_status": "Supply through pharmacies only",
  "interchangeable_code": "IC0098-002-002"
}

API reference MCP server Plans

See everything about methotrexate.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it free Open in the console