Netherlands· NL-7da828f54f41

Methotrexaat Accord 10 mg, tabletten

A methotrexate product containing methotrexaat, registered in Netherlands by Accord Healthcare B.V.. The same ATC class is registered in 15 of our 19 countries.

ATC L04AX03

Checked against CBG-MEB (Netherlands) on September 29, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about methotrexaatAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Methotrexate is registered in 15 of 19 countries.

Countries holding a registration under ATC L04AX03 (methotrexate), each read from that country’s own register.

This record: Netherlands, from CBG-MEB (Netherlands)
9 of them publish a price we can compare per daily dose

Search methotrexate products by name

Methotrexate · ATC L04AX03

15 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Germany
Icelandprice
Ireland
Italyprice
Netherlands
Norwayprice
Polandprice
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of methotrexate costs, country by country.

Normalised to the WHO defined daily dose (2.5 mg), the median price runs from $0.16 in United States to $5.98 in Switzerland — a ×38 gap.

3 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown
US figures are pharmacy acquisition cost (CMS NADAC), not retail

Open the full comparison — free account Drug prices for market access

Methotrexate · price per daily dose (2.5 mg)

USD · FX 28 Sept 2026

CH Switzerland$5.98
IT Italy$0.20
US United States$0.16 (acquisition cost)

Median listed price per WHO defined daily dose, in each market that publishes a price. US = pharmacy acquisition cost (CMS NADAC), not a retail price. Open the full comparison

The record

At a glance

CBG-MEB (Netherlands)

Active substance: METHOTREXAAT
Manufacturer: Accord Healthcare B.V.
Country: Netherlands (NL)
ATC code: L04AX03
ATC class: Methotrexate
Defined daily dose: 2.5 mg, O
Reimbursed: Not published by this register
Source register: CBG-MEB (Netherlands)
Last checked: September 29, 2026

Packs & prices · 1

cbg_meb_id
120372

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

929 interactions on record for methotrexate.

Graded by severity as the source publishes them — 107 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check methotrexate against other medicines How interaction checks work

Methotrexate · interactions on record

929 records

107 severe
466 moderate
17 minor
309 info

Most severe, free to view

OmeprazoleA02BC01severe
PantoprazoleA02BC02severe
LansoprazoleA02BC03severe
RabeprazoleA02BC04severe

30 more interactions with mechanism and management, from a commercially licensed source.

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Methotrexate in 17 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All methotrexate products

Authorised across Europe · EMA

The same active substance is authorised in 30 EEA countries. Names it is sold under:

Austria · Ebetrexat, Methofill
Belgium · Basitrin, Emthexate
Bulgaria · Ebetrexat, Инжексат
Cyprus · Injexate, Methotrexate Accord
Czechia · Foxiemo, Injexate
Germany · Lantarel, Lantarel Fs
Denmark · Ebetrex, Emthexate
Estonia · Ebetrex, Metex
Spain · Bertanel, Imeth
Finland · Ebetrex, Injexate
France · Imenor, Imeth
United Kingdom (Northern Ireland) · Ebetrex, Injexate
Greece · Methobion, Methotrexate Pfizer
Croatia · Ebetrexat, Methofill
Hungary · Ebetrexat, Methofill
Ireland · Methofill, Methotrexate Abcur
Iceland · Jylamvo, Methotrexat Ebewe
Italy · Afslamet, Immutrex
Liechtenstein · Jylamvo, Nordimet
Lithuania · Ebetrexat, Metex
Luxembourg · Emthexate, Emthexate Teva Pharma
Latvia · Ebetrex, Metex
Malta · Methotrexate Aspire Pharma (Malta)
Norway · Ebetrex, Jylamvo
Poland · Ebetrexat, Metex
Portugal · Fauldexato, Ledertrexato
Romania · Methotrexat Ebewe, Metorthrit
Sweden · Ebetrex, Injexate
Slovenia · Methofill, Metoject
Slovakia · Foxiemo, Injexate

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/b03d10f0-3f11-4481-88fc-142677ee6aaa
GET /v1/drugs/b03d10f0-3f11-4481-88fc-142677ee6aaa?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Tablet",
  "route": "Oraal gebruik",
  "soort": "RVG",
  "source": "cbg_meb",
  "smpc_url": "https://www.geneesmiddeleninformatiebank.nl/smpc/h120372_smpc.pdf",
  "strength": null,
  "atc_label": "Methotrexate",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/rvg120372",
  "excipients": [
    "CALCIUMWATERSTOFFOSFAAT 0-WATER (E 341)",
    "CELLULOSE, MICROKRISTALLIJN (E 460(i))",
    "LACTOSE 1-WATER",
    "MAGNESIUMSTEARAAT (E 470b)",
    "NATRIUMZETMEELGLYCOLAAT",
    "TALK (E 553b)"
  ],
  "substances": [
    "METHOTREXAAT"
  ],
  "leaflet_url": "https://www.geneesmiddeleninformatiebank.nl/bijsluiters/h120372.pdf",
  "authorised_at": "2018/07/19",
  "procedure_number": "IE/H/0477/002",
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "120372",
  "additional_monitoring": "N"
}

API reference MCP server Plans

See everything about methotrexate.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it free Open in the console