United States· US:59011-271_a4f435c1-f825-4252-b9e2-d3a04a674ff3
Hysingla ER
A hydrocodone product containing hydrocodone bitartrate, registered in United States by Knoa Pharma LLC. The same ATC class is registered in 3 of our 19 countries.
Checked against FDA National Drug Code directory (United States) on
Informational only — not a medical device.
Where it is registered
Hydrocodone is registered in 3 of 19 countries.
Countries holding a registration under ATC R05DA03 (hydrocodone), each read from that country’s own register.
- This record: United States, from FDA National Drug Code directory (United States)
- 2 of them publish a price we can compare per daily dose
Hydrocodone · ATC R05DA03
3 / 19 countries
- Canada
- Norwayprice
- United Statesprice
Price per daily dose
What a daily dose of hydrocodone costs, country by country.
Normalised to the WHO defined daily dose (15 mg), so markets compare like for like.
- United States: $9.50 per daily dose (median across products in the class)
- Public list prices, converted to USD at the rate date shown
Hydrocodone · price per daily dose (15 mg)
USD · FX 28 Sept 2026
- US United States$9.50 (acquisition cost)
The record
At a glance
FDA National Drug Code directory (United States)- Active substance
- hydrocodone bitartrate
- Manufacturer
- Knoa Pharma LLC
- Country
- United States (US)
- ATC code
- R05DA03
- ATC class
- Hydrocodone
- Defined daily dose
- 15 mg, O
- Reimbursed
- Not published by this register
- Source register
- FDA National Drug Code directory (United States)
- Last checked
- September 12, 2026
Packs & prices · 1
- ndc11590112716060 TABLET, EXTENDED RELEASE in 1 BOTTLE, PLASTIC (59011-271-60)
Regulatory notes
Interactions
593 interactions on record for hydrocodone.
Graded by severity as the source publishes them — 221 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Hydrocodone · interactions on record
593 records
- 221 severe
- 369 moderate
Most severe, free to view
- ClotrimazoleA01AB18severe
- CimetidineA02BA01severe
- TriflupromazinA04AD06severe
- AprepitantA04AD12severe
3 more interactions with mechanism and management, from a commercially licensed source.
Sign in to check- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Hydrocodone in 2 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/fda54958-9b81-4e8d-a03b-33c6897a160b GET /v1/drugs/fda54958-9b81-4e8d-a03b-33c6897a160b?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"unii": {
"unii": "NO70W886KK",
"rxcui": "142439",
"inchikey": "JMBRWJAVUIITGV-LNNMZZBZSA-N",
"display_name": "HYDROCODONE BITARTRATE",
"substance_type": "chemical",
"ingredient_type": "INGREDIENT SUBSTANCE"
},
"route": "ORAL",
"livertox": {
"summary": null,
"livertox_id": null,
"hepatotoxicity_score": 5
},
"spl_meta": {
"b7d23ac2-e776-9f62-3290-c64c2d6eb353": {
"match": "brand_token",
"title": "HYSINGLA ER (HYDROCODONE BITARTRATE) TABLET, EXTENDED RELEASE [KNOA PHARMA LLC]",
"spl_version": "16",
"published_date": "2026-05-13"
}
},
"productid": "59011-271_a4f435c1-f825-4252-b9e2-d3a04a674ff3",
"productndc": "59011-271",
"dosage_form": "TABLET, EXTENDED RELEASE",
"orange_book": {
"appl_no": "206627",
"products": [
{
"rs": true,
"rld": true,
"te_code": "AB",
"strength": "20MG",
"product_no": "001",
"approval_date": "Nov 20, 2014"
},
{
"rs": false,
"rld": true,
"te_code": "AB",
"strength": "30MG",
"product_no": "002",
"approval_date": "Nov 20, 2014"
},
{
"rs": false,
"rld": true,
"te_code": "AB",
"strength": "40MG",
"product_no": "003",
"approval_date": "Nov 20, 2014"
},
{
"rs": false,
"rld": true,
"te_code": "AB",
"strength": "60MG",
"product_no": "004",
"approval_date": "Nov 20, 2014"
},
{
"rs": false,
"rld": true,
"te_code": "AB",
"strength": "80MG",
"product_no": "005",
"approval_date": "Nov 20, 2014"
},
{
"rs": false,
"rld": true,
"te_code": "AB",
"strength": "100MG",
"product_no": "006",
"approval_date": "Nov 20, 2014"
},
{
"rs": false,
"rld": true,
"te_code": null,
"strength": "120MG",
"product_no": "007",
"approval_date": "Nov 20, 2014"
}
],
"appl_type": "N"
},
"dea_schedule": "CII",
"product_type": "HUMAN PRESCRIPTION DRUG",
"substance_name": "HYDROCODONE BITARTRATE",
"proprietary_name": "Hysingla ER",
"active_ingred_unit": "mg/1",
"application_number": "NDA206627",
"marketing_category": "NDA",
"nonproprietary_name": "hydrocodone bitartrate",
"start_marketing_date": "20150115",
"active_numerator_strength": "20"
}See everything about hydrocodone.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.