United Kingdom· GB-APID-34777311000001100
Methofill 12.5mg/0.25ml solution for injection pre-filled injector
A methotrexate product containing methotrexate, registered in United Kingdom by Accord-UK Ltd. The same ATC class is registered in 15 of our 19 countries.
Checked against NHS dm+d (United Kingdom) on
Informational only — not a medical device.
Where it is registered
Methotrexate is registered in 15 of 19 countries.
Countries holding a registration under ATC L04AX03 (methotrexate), each read from that country’s own register.
- This record: United Kingdom, from NHS dm+d (United Kingdom)
- 9 of them publish a price we can compare per daily dose
Methotrexate · ATC L04AX03
15 / 19 countries
- Belgiumprice
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Germany
- Icelandprice
- Ireland
- Italyprice
- Netherlands
- Norwayprice
- Polandprice
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of methotrexate costs, country by country.
Normalised to the WHO defined daily dose (2.5 mg), the median price runs from $0.16 in United States to $5.98 in Switzerland — a ×38 gap.
- 3 markets with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
- US figures are pharmacy acquisition cost (CMS NADAC), not retail
Methotrexate · price per daily dose (2.5 mg)
USD · FX 28 Sept 2026
- CH Switzerland$5.98
- IT Italy$0.20
- US United States$0.16 (acquisition cost)
The record
At a glance
NHS dm+d (United Kingdom)- Active substance
- Methotrexate
- Manufacturer
- Accord-UK Ltd
- Country
- United Kingdom (GB)
- ATC code
- L04AX03
- ATC class
- Methotrexate
- Defined daily dose
- 2.5 mg, O
- Reimbursed
- Not published by this register
- Source register
- NHS dm+d (United Kingdom)
- Last checked
- September 13, 2026
Packs & prices · 2
- gtin5055565737347
- gtin05055565737347
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
929 interactions on record for methotrexate.
Graded by severity as the source publishes them — 107 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Methotrexate · interactions on record
929 records
- 107 severe
- 466 moderate
- 17 minor
- 309 info
Most severe, free to view
- OmeprazoleA02BC01severe
- PantoprazoleA02BC02severe
- LansoprazoleA02BC03severe
- RabeprazoleA02BC04severe
30 more interactions with mechanism and management, from a commercially licensed source.
Sign in to check- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Methotrexate in 17 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- CzechiaFOXIEMOeasyMed s.r.o., Praha 10
- SwitzerlandJylamvo
- NetherlandsBasitrin 10 mg=0,267 ml, oplossing voor injectie in een voorgevulde spuit 37,5 mg/mlBasic Pharma Manufacturing B.V.
- BelgiumBasitrin 10 mgBasic Pharma Manufacturing
- SpainBERTANEL 10 mg/1 ml SOLUCION INYECTABLE EN JERINGA PRECARGADAEbewe Pharma Ges.M.B.H. Nfg.Kg
- SwedenEbetrex 2,5 mg TablettEBEWE Pharma Ges.m.b.H.Nfg.KG
- FinlandEbetrexEbewe Pharma Ges.m.b.H. Nfg.KG
- United StatesJYLAMVOSHORLA ONCOLOGY INC.
Authorised across Europe · EMA
The same active substance is authorised in 30 EEA countries. Names it is sold under:
- Austria · Ebetrexat, Methofill
- Belgium · Basitrin, Emthexate
- Bulgaria · Ebetrexat, Инжексат
- Cyprus · Injexate, Methotrexate Accord
- Czechia · Foxiemo, Injexate
- Germany · Lantarel, Lantarel Fs
- Denmark · Ebetrex, Emthexate
- Estonia · Ebetrex, Metex
- Spain · Bertanel, Imeth
- Finland · Ebetrex, Injexate
- France · Imenor, Imeth
- Greece · Methobion, Methotrexate Pfizer
- Croatia · Ebetrexat, Methofill
- Hungary · Ebetrexat, Methofill
- Ireland · Methofill, Methotrexate Abcur
- Iceland · Jylamvo, Methotrexat Ebewe
- Italy · Afslamet, Immutrex
- Liechtenstein · Jylamvo, Nordimet
- Lithuania · Ebetrexat, Metex
- Luxembourg · Emthexate, Emthexate Teva Pharma
- Latvia · Ebetrex, Metex
- Malta · Methotrexate Aspire Pharma (Malta)
- Netherlands · Basitrin, Ebetrex
- Norway · Ebetrex, Jylamvo
- Poland · Ebetrexat, Metex
- Portugal · Fauldexato, Ledertrexato
- Romania · Methotrexat Ebewe, Metorthrit
- Sweden · Ebetrex, Injexate
- Slovenia · Methofill, Metoject
- Slovakia · Foxiemo, Injexate
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of NHS dm+d (United Kingdom). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/f9da441c-7235-4635-be18-565a960295e3 GET /v1/drugs/f9da441c-7235-4635-be18-565a960295e3?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"apid": "34777311000001100",
"desc": "Methofill 12.5mg/0.25ml solution for injection pre-filled injector (Accord-UK Ltd)",
"form": "Solution for injection",
"vpid": "24594411000001107",
"source": "dmd",
"vtm_id": "776732000",
"strength": "50 mg",
"substance": "Methotrexate",
"ingredient": "Methotrexate",
"supplier_code": "18471011000001103"
}See everything about methotrexate.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.