Japan· JP-3999014F5010
タクロリムス水和物
A tacrolimus product containing タクロリムス水和物, registered in Japan, on the national reimbursement list. The same ATC class is registered in 16 of our 19 countries.
Checked against MHLW / PMDA (Japan) on
Informational only — not a medical device.
Where it is registered
Tacrolimus is registered in 16 of 19 countries.
Countries holding a registration under ATC L04AD02 (tacrolimus), each read from that country’s own register.
- This record: Japan, from MHLW / PMDA (Japan)
- 9 of them publish a price we can compare per daily dose
Tacrolimus · ATC L04AD02
16 / 19 countries
- Belgiumprice
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Germany
- Icelandprice
- Ireland
- Italyprice
- Japan
- Netherlands
- Norwayprice
- Polandprice
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of tacrolimus costs, country by country.
Normalised to the WHO defined daily dose (5 mg), the median price runs from $0.77 in United States to $15.16 in Switzerland — a ×20 gap.
- 4 markets with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
- US figures are pharmacy acquisition cost (CMS NADAC), not retail
Tacrolimus · price per daily dose (5 mg)
USD · FX 28 Sept 2026
- CH Switzerland$15.16
- IT Italy$8.99
- ES Spain$6.82
- US United States$0.77 (acquisition cost)
The record
At a glance
MHLW / PMDA (Japan)- Active substance
- タクロリムス水和物
- Manufacturer
- —
- Country
- Japan (JP)
- ATC code
- L04AD02
- ATC class
- Tacrolimus
- Defined daily dose
- 5 mg, O
- Reimbursed
- Yes
- Source register
- MHLW / PMDA (Japan)
- Last checked
- September 25, 2026
Packs & prices · 0
No packs listed by the register for this record.
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
1075 interactions on record for tacrolimus.
Graded by severity as the source publishes them — 238 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Tacrolimus · interactions on record
1075 records
- 238 severe
- 543 moderate
- 18 minor
- 217 info
Most severe, free to view
- ClotrimazoleA01AB18severe
- OmeprazoleA02BC01severe
- LansoprazoleA02BC03severe
- EsomeprazoleA02BC05severe
59 more interactions with mechanism and management, from a commercially licensed source.
Sign in to check- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same class
Other records under L04AD02
Tacrolimus, as other registers publish it.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of MHLW / PMDA (Japan). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/f8faea46-e15d-4a2d-97ae-f36855823630 GET /v1/drugs/f8faea46-e15d-4a2d-97ae-f36855823630?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"spec": "５ｍｇ１錠",
"marks": null,
"source": "mhlw",
"remarks": null,
"yj_code": "3999014F5010",
"category": "内用薬",
"price_yen": 557.7,
"generic_name": "タクロリムス水和物",
"product_name_jp": null,
"therapeutic_class": "3999",
"transitional_expiry": null
}See everything about tacrolimus.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.