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United States· US:71335-2400_38984dde-4201-4bd1-9a7c-44537f91be8c

Bupropion hydrochloride

A bupropion product containing bupropion hydrochloride, registered in United States by Bryant Ranch Prepack. The same ATC class is registered in 13 of our 19 countries.

ATC N06AX12Orange BookUS label

Checked against FDA National Drug Code directory (United States) on

Informational only — not a medical device.

SOURCE REGISTER · USFDA National Drug Code directory (Unite…normalisedBupropion hydrochlorideATCN06AX12REGISTER NO.US:71335-2400_38984dd…PACKS LISTED6CHECKEDSeptember 12, 2026

Where it is registered

Bupropion is registered in 13 of 19 countries.

Countries holding a registration under ATC N06AX12 (bupropion), each read from that country’s own register.

  • This record: United States, from FDA National Drug Code directory (United States)
  • 9 of them publish a price we can compare per daily dose

Bupropion · ATC N06AX12

13 / 19 countries

  • Belgiumprice
  • Canada
  • Czechiaprice
  • Denmark
  • Finlandprice
  • Icelandprice
  • Ireland
  • Italyprice
  • Netherlands
  • Norwayprice
  • Polandprice
  • Switzerlandprice
  • United Statesprice
Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of bupropion costs, country by country.

Normalised to the WHO defined daily dose (0.15 g), the median price runs from $0.10 in United States to $1.25 in Switzerland — a ×12 gap.

  • United States: $0.10 per daily dose (median across products in the class)
  • Public list prices, converted to USD at the rate date shown
  • US figures are pharmacy acquisition cost (CMS NADAC), not retail

Bupropion · price per daily dose (0.15 g)

USD · FX 28 Sept 2026

  • CH Switzerland$1.25
  • IT Italy$0.90
  • US United States$0.10 (acquisition cost)
Median listed price per WHO defined daily dose, in each market that publishes a price. US = pharmacy acquisition cost (CMS NADAC), not a retail price. Open the full comparison

The record

At a glance

FDA National Drug Code directory (United States)
Active substance
Bupropion hydrochloride
Manufacturer
Bryant Ranch Prepack
Country
United States (US)
ATC code
N06AX12
ATC class
Bupropion
Defined daily dose
0.15 g, O
Reimbursed
Not published by this register
Source register
FDA National Drug Code directory (United States)
Last checked
September 12, 2026

Packs & prices · 6

  • ndc11
    7133524001
    60 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2400-1)
  • ndc11
    7133524002
    180 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2400-2)
  • ndc11
    7133524003
    30 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2400-3)
  • ndc11
    7133524004
    90 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2400-4)
  • ndc11
    7133524005
    120 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2400-5)
  • ndc11
    7133524006
    28 TABLET, EXTENDED RELEASE in 1 BOTTLE (71335-2400-6)

Regulatory notes

UNII (FDA substance ID)
ZG7E5POY8O
BUPROPION HYDROCHLORIDE
RxCUI 203204
Orange Book
A216800
AB1AB1AB1
DailyMed SPL labels
1 version tracked

Interactions

808 interactions on record for bupropion.

Graded by severity as the source publishes them — 230 severe. Severity grades are free for everyone; mechanism and management come with Growth.

  • Severity for every pair — free, no plan needed
  • The source, licence and sync date on every record
  • Mechanism and what to do for each pair — Growth plan

Bupropion · interactions on record

808 records

  • 230 severe
  • 217 moderate
  • 4 minor
  • 316 info

Most severe, free to view

  • MetoclopramideA03FA01severe
  • OndansetronA04AA01severe
  • GranisetronA04AA02severe
  • DolasetronA04AA04severe

41 more interactions with mechanism and management, from a commercially licensed source.

Sign in to check
  • Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Mechanism and what to do, in the interaction check
Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload
GET /v1/drugs/f40222c9-7107-48e8-a153-7027f40e4593
GET /v1/drugs/f40222c9-7107-48e8-a153-7027f40e4593?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "unii": {
    "unii": "ZG7E5POY8O",
    "rxcui": "203204",
    "inchikey": "HEYVINCGKDONRU-UHFFFAOYSA-N",
    "display_name": "BUPROPION HYDROCHLORIDE",
    "substance_type": "chemical",
    "ingredient_type": "INGREDIENT SUBSTANCE"
  },
  "route": "ORAL",
  "livertox": {
    "summary": null,
    "livertox_id": null,
    "hepatotoxicity_score": 3
  },
  "spl_meta": {
    "cefaaa17-f79a-4ba6-8f97-a59f60e07b75": {
      "match": "brand_token",
      "title": "BUPROPION HYDROCHLORIDE (XL) (BUPROPION HYDROCHLORIDE) TABLET, FILM COATED, EXTENDED RELEASE [BRYANT RANCH PREPACK]",
      "spl_version": "105",
      "published_date": "2026-06-01"
    }
  },
  "productid": "71335-2400_38984dde-4201-4bd1-9a7c-44537f91be8c",
  "productndc": "71335-2400",
  "dosage_form": "TABLET, EXTENDED RELEASE",
  "orange_book": {
    "appl_no": "216800",
    "products": [
      {
        "rs": false,
        "rld": false,
        "te_code": "AB1",
        "strength": "100MG",
        "product_no": "001",
        "approval_date": "May 31, 2023"
      },
      {
        "rs": false,
        "rld": false,
        "te_code": "AB1",
        "strength": "150MG",
        "product_no": "002",
        "approval_date": "May 31, 2023"
      },
      {
        "rs": false,
        "rld": false,
        "te_code": "AB1",
        "strength": "200MG",
        "product_no": "003",
        "approval_date": "May 31, 2023"
      }
    ],
    "appl_type": "A"
  },
  "dea_schedule": null,
  "product_type": "HUMAN PRESCRIPTION DRUG",
  "substance_name": "BUPROPION HYDROCHLORIDE",
  "proprietary_name": "Bupropion hydrochloride",
  "active_ingred_unit": "mg/1",
  "application_number": "ANDA216800",
  "marketing_category": "ANDA",
  "nonproprietary_name": "Bupropion hydrochloride",
  "start_marketing_date": "20230531",
  "active_numerator_strength": "200"
}

See everything about bupropion.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.