Netherlands· NL-6bc2cdf5c65e

Ayupine 12,5 mg, orodispergeerbare tabletten

A clozapine product containing clozapine, registered in Netherlands by Synthon B.V.. The same ATC class is registered in 17 of our 19 countries.

ATC N05AH02

Checked against CBG-MEB (Netherlands) on September 29, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about clozapineAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Clozapine is registered in 17 of 19 countries.

Countries holding a registration under ATC N05AH02 (clozapine), each read from that country’s own register.

This record: Netherlands, from CBG-MEB (Netherlands)
10 of them publish a price we can compare per daily dose

Search clozapine products by name

Clozapine · ATC N05AH02

17 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Franceprice
Germany
Icelandprice
Ireland
Italyprice
Netherlands
Norwayprice
Polandprice
Sweden
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of clozapine costs, country by country.

Normalised to the WHO defined daily dose (0.3 g), the median price runs from $1.63 in France to $2.78 in Switzerland — a ×1.7 gap.

3 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Clozapine · price per daily dose (0.3 g)

USD · FX 28 Sept 2026

CH Switzerland$2.78
IT Italy$2.38
FR France$1.63

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

CBG-MEB (Netherlands)

Active substance: CLOZAPINE
Manufacturer: Synthon B.V.
Country: Netherlands (NL)
ATC code: N05AH02
ATC class: Clozapine
Defined daily dose: 0.3 g, O
Reimbursed: Not published by this register
Source register: CBG-MEB (Netherlands)
Last checked: September 29, 2026

Packs & prices · 1

cbg_meb_id
122055

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

620 interactions on record for clozapine.

Graded by severity as the source publishes them — 306 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check clozapine against other medicines How interaction checks work

Clozapine · interactions on record

620 records

306 severe
197 moderate
4 minor
61 info

Most severe, free to view

PapaverineA03AD01severe
MetoclopramideA03FA01severe
CisaprideA03FA02severe
OndansetronA04AA01severe

52 more interactions with mechanism and management, from a commercially licensed source.

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Clozapine in 16 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All clozapine products

Authorised across Europe · EMA

The same active substance is authorised in 29 EEA countries. Names it is sold under:

Austria · Clozapin Accord, Clozapin Ratiopharm
Belgium · Clozapine Sandoz, Leponex
Bulgaria · Ексклоза, Клозапин Акорд
Cyprus · Clozapine Accord, Clozarem
Czechia · Clozapin Desitin, Leponex
Germany · Clozapin 1a-Pharma, Clozapin Abz
Denmark · Clozapin Accord, Clozapin Hexal
Estonia · Clozapine Accord, Leponex
Spain · Clozabrain, Clozapina Aurovitas
Finland · Clozapine Accord, Clozapine Stada
France · Clozapine Accord, Clozapine Aristo
United Kingdom (Northern Ireland) · Clozapine, Clozapine Viatris
Greece · Leponex
Croatia · Klozapin Accord, Klozapin Alpha-Medical
Hungary · Clozapine Gerot, Clozapine Stada
Ireland · Clozaril, Denzapine
Iceland · Clozapin Medical, Clozapine Actavis
Italy · Clozapina Accord, Clozapina Aurobindo
Lithuania · Clozapine Accord, Leponex
Luxembourg · Leponex
Latvia · Clozapine Accord, Leponex
Malta · Clozarem
Norway · Clozapin Hexal, Clozapine Accord
Poland · Clopizam, Clozapine Hasco
Portugal · Clozapina Aristo, Clozapina Aurovitas
Romania · Leponex
Sweden · Clozapine Accord, Clozapine Actavis
Slovenia · Klozapin Accord, Leponex
Slovakia · Clozapine Accord, Leponex

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/f27d5d44-b94e-40f3-ad2b-c03e7b017820
GET /v1/drugs/f27d5d44-b94e-40f3-ad2b-c03e7b017820?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Orodispergeerbare tablet",
  "route": "Oraal gebruik",
  "soort": "RVG",
  "source": "cbg_meb",
  "smpc_url": "https://www.geneesmiddeleninformatiebank.nl/smpc/h122055_smpc.pdf",
  "strength": null,
  "atc_label": "Clozapine",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/rvg122055",
  "excipients": [
    "ASPARTAAM (E 951)",
    "CELLULOSE, MICROKRISTALLIJN (E 460(i))",
    "CROSPOVIDON (E 1202)",
    "GLYCEROLTRIACETAAT (E 1518)",
    "IJZEROXIDE GEEL (E 172)",
    "MAGNESIUMSTEARAAT (E 470b)",
    "MALTODEXTRINE",
    "MANNITOL (D-) (E 421)",
    "NATRIUMZETMEELOCTENYLSUCCINAAT (E 1450)",
    "PEPERMUNTSMAAKSTOF",
    "SILICIUMDIOXIDE (E 551)"
  ],
  "substances": [
    "CLOZAPINE"
  ],
  "leaflet_url": "https://www.geneesmiddeleninformatiebank.nl/bijsluiters/h122055.pdf",
  "authorised_at": "2019/01/23",
  "procedure_number": "NL/H/4201/001",
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "122055",
  "additional_monitoring": "N"
}

API reference MCP server Plans

See everything about clozapine.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it free Open in the console