Canada· CA-DIN-02182777

METHOTREXATE INJECTION USP

A methotrexate product containing methotrexate (methotrexate sodium), registered in Canada by PFIZER CANADA ULC. The same ATC class is registered in 12 of our 19 countries.

ATC L01BA01

Checked against Health Canada Drug Product Database (Canada) on October 1, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about methotrexate (methotrexate sodium)Answers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Methotrexate is registered in 12 of 19 countries.

Countries holding a registration under ATC L01BA01 (methotrexate), each read from that country’s own register.

This record: Canada, from Health Canada Drug Product Database (Canada)
7 of them publish a price we can compare per daily dose

Search methotrexate products by name

Methotrexate · ATC L01BA01

12 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Icelandprice
Ireland
Japan
Netherlands
Norwayprice
Polandprice
Switzerlandprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

The record

At a glance

Health Canada Drug Product Database (Canada)

Active substance: METHOTREXATE (METHOTREXATE SODIUM)
Manufacturer: PFIZER CANADA ULC
Country: Canada (CA)
ATC code: L01BA01
ATC class: Methotrexate
Reimbursed: Not published by this register
Source register: Health Canada Drug Product Database (Canada)
Last checked: October 1, 2026

Packs & prices · 0

No packs listed by the register for this record.

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

949 interactions on record for methotrexate.

Graded by severity as the source publishes them — 107 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check methotrexate against other medicines How interaction checks work

Methotrexate · interactions on record

949 records

107 severe
466 moderate
17 minor
309 info

Most severe, free to view

OmeprazoleA02BC01severe
PantoprazoleA02BC02severe
LansoprazoleA02BC03severe
RabeprazoleA02BC04severe

50 more interactions with mechanism and management, from a commercially licensed source.

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Methotrexate in 17 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All methotrexate products

Authorised across Europe · EMA

The same active substance is authorised in 31 EEA countries. Names it is sold under:

Austria · Ebetrexat, Methofill
Belgium · Basitrin, Emthexate
Bulgaria · Ebetrexat, Инжексат
Cyprus · Injexate, Methotrexate Accord
Czechia · Foxiemo, Injexate
Germany · Lantarel, Lantarel Fs
Denmark · Ebetrex, Emthexate
Estonia · Ebetrex, Metex
Spain · Bertanel, Imeth
Finland · Ebetrex, Injexate
France · Imenor, Imeth
United Kingdom (Northern Ireland) · Ebetrex, Injexate
Greece · Methobion, Methotrexate Pfizer
Croatia · Ebetrexat, Methofill
Hungary · Ebetrexat, Methofill
Ireland · Methofill, Methotrexate Abcur
Iceland · Jylamvo, Methotrexat Ebewe
Italy · Afslamet, Immutrex
Liechtenstein · Jylamvo, Nordimet
Lithuania · Ebetrexat, Metex
Luxembourg · Emthexate, Emthexate Teva Pharma
Latvia · Ebetrex, Metex
Malta · Methotrexate Aspire Pharma (Malta)
Netherlands · Basitrin, Ebetrex
Norway · Ebetrex, Jylamvo
Poland · Ebetrexat, Metex
Portugal · Fauldexato, Ledertrexato
Romania · Methotrexat Ebewe, Metorthrit
Sweden · Ebetrex, Injexate
Slovenia · Methofill, Metoject
Slovakia · Foxiemo, Injexate

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of Health Canada Drug Product Database (Canada). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/edb654e3-8de7-4ebe-bf2a-b913f90009e9
GET /v1/drugs/edb654e3-8de7-4ebe-bf2a-b913f90009e9?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "din": "02182777",
  "form": "SOLUTION",
  "class": "Human",
  "routes": [
    "INTRAVENOUS",
    "INTRA-ARTERIAL",
    "INTRAMUSCULAR"
  ],
  "source": "health_canada_dpd",
  "status": "MARKETED",
  "atc_raw": "L01BA01",
  "schedule": [
    "Prescription"
  ],
  "drug_code": "42844",
  "strengths": [
    "25 MG"
  ],
  "ahfs_class": null,
  "substances": [
    "METHOTREXATE (METHOTREXATE SODIUM)"
  ],
  "product_categorization": null
}

API reference MCP server Plans

See everything about methotrexate.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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