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Netherlands· NL-d3f5b7c20245

Appref 12,5 mg/1000 mg filmomhulde tabletten

A metformin and empagliflozin product containing empagliflozine + metforminehydrochloride, registered in Netherlands by Meren Pharma B.V.. The same ATC class is registered in 13 of our 19 countries.

ATC A10BD20

Checked against CBG-MEB (Netherlands) on

Informational only — not a medical device.

SOURCE REGISTER · NLCBG-MEB (Netherlands)normalisedAppref 12,5 mg/1000 mg filmomhulde ta…ATCA10BD20REGISTER NO.NL-d3f5b7c20245PACKS LISTED1CHECKEDSeptember 29, 2026
Compare price across countriesPer daily dose · free accountAsk the assistant about empagliflozine + metforminehydrochlorideAnswers with sources · free accountCheck interactionsSeverity free · mechanism on Growth

Where it is registered

Metformin and empagliflozin is registered in 13 of 19 countries.

Countries holding a registration under ATC A10BD20 (metformin and empagliflozin), each read from that country’s own register.

  • This record: Netherlands, from CBG-MEB (Netherlands)
  • 8 of them publish a price we can compare per daily dose
Search metformin and empagliflozin products by name

Metformin and empagliflozin · ATC A10BD20

13 / 19 countries

  • Belgiumprice
  • Canada
  • Czechiaprice
  • Denmark
  • Finlandprice
  • Icelandprice
  • Ireland
  • Netherlands
  • Norwayprice
  • Polandprice
  • Switzerlandprice
  • United Kingdom
  • United Statesprice
Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

The record

At a glance

CBG-MEB (Netherlands)
Active substance
EMPAGLIFLOZINE + METFORMINEHYDROCHLORIDE
Manufacturer
Meren Pharma B.V.
Country
Netherlands (NL)
ATC code
A10BD20
ATC class
Metformin and empagliflozin
Reimbursed
Not published by this register
Source register
CBG-MEB (Netherlands)
Last checked
September 29, 2026

Packs & prices · 1

  • cbg_meb_id
    133831

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Same medicine, other countries

Metformin and empagliflozin in 13 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All metformin and empagliflozin products

Authorised across Europe · EMA

The same active substance is authorised in 22 EEA countries. Names it is sold under:

  • Austria · Empagliflozin/Metformin Hcs
  • Belgium · Empagliflozine/Metformine Hcl Hcs
  • Bulgaria · Empafel Met 5 Mg/850 Mg, Емпафел Мет
  • Cyprus · Empagliflozin/Metformin Tad
  • Czechia · Mempoglyn
  • Denmark · Empagliflozin/Metformin Krka
  • Estonia · Mempoglyn
  • Spain · Empagliflozina/Metformina Krka
  • Greece · Mempoglyn
  • Croatia · Mempoglyn
  • Hungary · Mempoglyn
  • Ireland · Empagliflozin/Metformin Krka
  • Iceland · Appref, Empagliflozin-Metformin Adalvo
  • Liechtenstein · Synjardy
  • Lithuania · Mempoglyn
  • Luxembourg · Empagliflozin/Metformin Hcl Ab
  • Latvia · Mempoglyn
  • Malta · Appref, Empagliflozin-Metformin Adalvo
  • Norway · Empagliflozin/Metformin Krka, Synjardy
  • Portugal · Empagliflozina + Metformina Aurobindo, Empagliflozina + Metformina Generis
  • Romania · Mempoglyn
  • Slovenia · Emameten, Empagliflozin/Metformin Krka

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload
GET /v1/drugs/e4a27521-5b0e-4295-b268-d9a1214181fe
GET /v1/drugs/e4a27521-5b0e-4295-b268-d9a1214181fe?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Filmomhulde tablet",
  "route": "Oraal gebruik",
  "soort": "RVG",
  "source": "cbg_meb",
  "smpc_url": "https://www.geneesmiddeleninformatiebank.nl/smpc/h133831_smpc_en.pdf",
  "strength": null,
  "atc_label": "Metformin and empagliflozin",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/rvg133831",
  "excipients": [
    "CELLULOSE, MICROKRISTALLIJN (E 460(i))",
    "CROSCARMELLOSE  NATRIUM  (E 468)",
    "GLYCEROL MONOCAPRYLOCAPRAAT, TYPE I",
    "HYPROLOSE (E 463)",
    "IJZEROXIDE GEEL (E 172)",
    "MAGNESIUMSTEARAAT (E 470b)",
    "MAÏSZETMEEL",
    "NATRIUMLAURILSULFAAT",
    "POLYVINYLALCOHOL (E 1203)",
    "SILICIUMDIOXIDE (E 551)",
    "TALK (E 553b)",
    "TITAANDIOXIDE (E 171)"
  ],
  "substances": [
    "EMPAGLIFLOZINE",
    "METFORMINEHYDROCHLORIDE"
  ],
  "leaflet_url": "https://www.geneesmiddeleninformatiebank.nl/bijsluiters/h133831_piluk.pdf",
  "authorised_at": "2025/09/24",
  "procedure_number": "IS/H/0676/004",
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "133831",
  "additional_monitoring": "N"
}
API referenceMCP serverPlans

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This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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