Vagifem

{
  "unii": {
    "unii": "4TI98Z838E",
    "rxcui": "4083",
    "inchikey": "VOXZDWNPVJITMN-ZBRFXRBCSA-N",
    "display_name": "ESTRADIOL",
    "substance_type": "chemical",
    "ingredient_type": "INGREDIENT SUBSTANCE"
  },
  "route": "VAGINAL",
  "spl_meta": {
    "e5ad3cf6-dd96-4e64-af21-c1eee38d0b88": {
      "match": "brand_token",
      "title": "VAGIFEM (ESTRADIOL) INSERT [NOVO NORDISK]",
      "spl_version": "22",
      "published_date": "2025-02-12"
    }
  },
  "productid": "0169-5176_9564f4b5-dbf2-429a-b058-f240e296cec9",
  "productndc": "0169-5176",
  "dosage_form": "INSERT",
  "orange_book": {
    "appl_no": "020908",
    "products": [
      {
        "rs": false,
        "rld": true,
        "te_code": null,
        "strength": "25MCG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**",
        "product_no": "001",
        "approval_date": "Mar 26, 1999"
      },
      {
        "rs": true,
        "rld": true,
        "te_code": "AB",
        "strength": "10MCG",
        "product_no": "002",
        "approval_date": "Nov 25, 2009"
      }
    ],
    "appl_type": "N"
  },
  "dea_schedule": null,
  "product_type": "HUMAN PRESCRIPTION DRUG",
  "substance_name": "ESTRADIOL",
  "proprietary_name": "Vagifem",
  "active_ingred_unit": "ug/1",
  "application_number": "NDA020908",
  "marketing_category": "NDA",
  "nonproprietary_name": "estradiol",
  "start_marketing_date": "20100111",
  "active_numerator_strength": "10"
}