United Kingdom· GB-APID-9453611000001106
Methotrexate 17.5mg/0.7ml solution for injection pre-filled syringes
A methotrexate product containing methotrexate, registered in United Kingdom by Special Order. The same ATC class is registered in 15 of our 19 countries.
Checked against NHS dm+d (United Kingdom) on
Informational only — not a medical device.
Where it is registered
Methotrexate is registered in 15 of 19 countries.
Countries holding a registration under ATC L04AX03 (methotrexate), each read from that country’s own register.
- This record: United Kingdom, from NHS dm+d (United Kingdom)
- 9 of them publish a price we can compare per daily dose
Methotrexate · ATC L04AX03
15 / 19 countries
- Belgiumprice
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Germany
- Icelandprice
- Ireland
- Italyprice
- Netherlands
- Norwayprice
- Polandprice
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of methotrexate costs, country by country.
Normalised to the WHO defined daily dose (2.5 mg), the median price runs from $0.16 in United States to $5.98 in Switzerland — a ×38 gap.
- 3 markets with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
- US figures are pharmacy acquisition cost (CMS NADAC), not retail
Methotrexate · price per daily dose (2.5 mg)
USD · FX 28 Sept 2026
- CH Switzerland$5.98
- IT Italy$0.20
- US United States$0.16 (acquisition cost)
The record
At a glance
NHS dm+d (United Kingdom)- Active substance
- Methotrexate
- Manufacturer
- Special Order
- Country
- United Kingdom (GB)
- ATC code
- L04AX03
- ATC class
- Methotrexate
- Defined daily dose
- 2.5 mg, O
- Reimbursed
- Not published by this register
- Source register
- NHS dm+d (United Kingdom)
- Last checked
- September 13, 2026
Packs & prices · 0
No packs listed by the register for this record.
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
929 interactions on record for methotrexate.
Graded by severity as the source publishes them — 107 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Methotrexate · interactions on record
929 records
- 107 severe
- 466 moderate
- 17 minor
- 309 info
Most severe, free to view
- OmeprazoleA02BC01severe
- PantoprazoleA02BC02severe
- LansoprazoleA02BC03severe
- RabeprazoleA02BC04severe
30 more interactions with mechanism and management, from a commercially licensed source.
Sign in to check- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Methotrexate in 17 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- CzechiaFOXIEMOeasyMed s.r.o., Praha 10
- SwedenInjexate 25 mg Injektionsvätska, lösning i förfylld injektorAccord Healthcare B.V.
- PolandMetex PENmedac Gesellschaft fuer klinische Spezialpraeparate mbH
- NorwayEbetrexatEBEWE Pharma Ges.m.b.H Nfg. KG
- SwitzerlandMetoject 25 mg, InjektionslösungGebro Pharma AG
- BelgiumBasitrin 25 mgBasic Pharma Manufacturing
- IcelandMetojectpenmedac Gesellschaft für klinische Spezialpräparate GmbH
- ItalyAFSLAMET*S.F. GROUP S.R.L.
Authorised across Europe · EMA
The same active substance is authorised in 30 EEA countries. Names it is sold under:
- Austria · Ebetrexat, Methofill
- Belgium · Basitrin, Emthexate
- Bulgaria · Ebetrexat, Инжексат
- Cyprus · Injexate, Methotrexate Accord
- Czechia · Foxiemo, Injexate
- Germany · Lantarel, Lantarel Fs
- Denmark · Ebetrex, Emthexate
- Estonia · Ebetrex, Metex
- Spain · Bertanel, Imeth
- Finland · Ebetrex, Injexate
- France · Imenor, Imeth
- Greece · Methobion, Methotrexate Pfizer
- Croatia · Ebetrexat, Methofill
- Hungary · Ebetrexat, Methofill
- Ireland · Methofill, Methotrexate Abcur
- Iceland · Jylamvo, Methotrexat Ebewe
- Italy · Afslamet, Immutrex
- Liechtenstein · Jylamvo, Nordimet
- Lithuania · Ebetrexat, Metex
- Luxembourg · Emthexate, Emthexate Teva Pharma
- Latvia · Ebetrex, Metex
- Malta · Methotrexate Aspire Pharma (Malta)
- Netherlands · Basitrin, Ebetrex
- Norway · Ebetrex, Jylamvo
- Poland · Ebetrexat, Metex
- Portugal · Fauldexato, Ledertrexato
- Romania · Methotrexat Ebewe, Metorthrit
- Sweden · Ebetrex, Injexate
- Slovenia · Methofill, Metoject
- Slovakia · Foxiemo, Injexate
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of NHS dm+d (United Kingdom). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/d0a873fd-d73a-4ff7-960c-f4589a248bbf GET /v1/drugs/d0a873fd-d73a-4ff7-960c-f4589a248bbf?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"apid": "9453611000001106",
"desc": "Methotrexate 17.5mg/0.7ml solution for injection pre-filled syringes (Special Order)",
"form": "Solution for injection",
"vpid": "9468511000001106",
"source": "dmd",
"vtm_id": "776732000",
"strength": "25 mg",
"substance": "Methotrexate",
"ingredient": "Methotrexate sodium",
"supplier_code": "8286711000001104"
}See everything about methotrexate.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.