United Kingdom· GB-APID-18271511000001105
Kliofem tablets
A medicinal product containing estradiol + norethisterone acetate, registered in United Kingdom by Necessity Supplies Ltd.
Checked against NHS dm+d (United Kingdom) on
Informational only — not a medical device.
The record
At a glance
NHS dm+d (United Kingdom)- Active substance
- Estradiol + Norethisterone acetate
- Manufacturer
- Necessity Supplies Ltd
- Country
- United Kingdom (GB)
- ATC code
- —
- Reimbursed
- Not published by this register
- Source register
- NHS dm+d (United Kingdom)
- Last checked
- September 13, 2026
Packs & prices · 0
No packs listed by the register for this record.
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Same medicine, other countries
Estradiol + norethisterone acetate in 13 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- United StatesABIGALEXiromed LLC
- NorwayActivelleNovo Nordisk A/S
- SwitzerlandActivelle
- SwedenActivelle 1 mg/0,5 mg Filmdragerad tablettNovo Nordisk A/S
- PolandActivelleNovo Nordisk A/S
- IcelandActivelleNovo Nordisk A/S*
- SpainACTIVELLE 1 mg/0,5 mg COMPRIMIDOS RECUBIERTOS CON PELICULAIsdin S.A.
- FinlandCliovelleDr. Kade Pharmazeutische Fabrik GmbH
Authorised across Europe · EMA
The same active substance is authorised in 27 EEA countries. Names it is sold under:
- Austria · Activelle, Kliogest
- Belgium · Activelle, Activelle Minor
- Bulgaria · Активел, Трисеквенс
- Cyprus · Trisequens
- Czechia · Activelle, Kliogest
- Germany · Activelle, Cliovelle
- Denmark · Activelle, Activelle Low
- Estonia · Activelle, Eviana
- Spain · Activelle, Duofemme
- Finland · Activelle, Cliovelle
- France · Activelle, Kliogest
- Greece · Trisequens
- Croatia · Activelle, Novofem
- Hungary · Activelle, Kliogest
- Ireland · Activelle, Kliogest
- Iceland · Activelle, Activelle Low
- Italy · Activelle
- Lithuania · Activelle, Kliogest
- Luxembourg · Activelle, Activelle Minor
- Latvia · Activelle, Kliogest
- Netherlands · Activelle
- Norway · Activelle, Cliovelle
- Poland · Cliovelle, Kliogest
- Portugal · Activelle, Kliogest
- Sweden · Activelle, Cliovelle
- Slovenia · Activelle, Kliogest
- Slovakia · Activelle, Novofem
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of NHS dm+d (United Kingdom). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/cd7de15d-fd59-49e1-8f48-211f548faac3 GET /v1/drugs/cd7de15d-fd59-49e1-8f48-211f548faac3?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"apid": "18271511000001105",
"desc": "Kliofem tablets (Necessity Supplies Ltd)",
"form": "Oral tablet",
"vpid": "41875111000001104",
"source": "dmd",
"vtm_id": "36410811000001100",
"strength": "1 mg",
"substance": "Estradiol + Norethisterone acetate",
"ingredient": "Norethisterone acetate",
"supplier_code": "2814701000001108"
}See everything about estradiol + norethisterone acetate.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.