United States· US:23155-517_fe40568f-ed8b-43fe-987f-839427a5924f

Neostigmine Methylsulfate

A anticholinesterases product containing neostigmine methylsulfate, registered in United States by Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.. The same ATC class is registered in 2 of our 19 countries.

In shortageATC N07AAOrange BookUS label

Checked against FDA National Drug Code directory (United States) on June 3, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about neostigmine methylsulfateAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Neostigmine methylsulfate is registered in 2 of 19 countries.

Countries holding a registration under ATC N07AA (anticholinesterases), each read from that country’s own register.

This record: United States, from FDA National Drug Code directory (United States)
2 of them publish a price we can compare per daily dose

Search neostigmine methylsulfate products by name

Neostigmine methylsulfate · ATC N07AA

2 / 19 countries

Polandprice
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

The record

At a glance

FDA National Drug Code directory (United States)

Active substance: Neostigmine Methylsulfate
Manufacturer: Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
Country: United States (US)
ATC code: N07AA
ATC class: Anticholinesterases
Reimbursed: Not published by this register
Source register: FDA National Drug Code directory (United States)
Last checked: June 3, 2026

Packs & prices · 1

ndc11
2315551741
10 VIAL in 1 CARTON (23155-517-41) / 10 mL in 1 VIAL (23155-517-31)

Regulatory notes

UNII (FDA substance ID)

98IMH7M386

NEOSTIGMINE METHYLSULFATE

RxCUI 7316

Orange Book

A208230

APAP

DailyMed SPL labels

1 version tracked

FDA shortage

Currently in shortage

Neostigmine Methylsulfate Injection

Same medicine, other countries

Neostigmine methylsulfate in 8 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All neostigmine methylsulfate products

Authorised across Europe · EMA

The same active substance is authorised in 17 EEA countries. Names it is sold under:

Austria · Neostig, Normastigmin
Cyprus · Neostigmine Cooper
Czechia · Syntostigmin
Germany · Neostig, Neostigmin Panpharma
Spain · Neostigmina Braun
France · Néostigmine Renaudin, Prostigmine
United Kingdom (Northern Ireland) · Neostigmine Methylsulfate Bp Hameln Pharma
Greece · Neostigmine Cooper
Croatia · Neostigmin Panpharma
Hungary · Neostigmine Kalceks, Stigmosan
Latvia · Neostigmine Kalceks
Netherlands · Neostigminemethylsulfaat Cf, Prostigmin
Poland · Polstigminum
Portugal · Neostigmina Braun
Romania · Miostin
Sweden · Neostigmin Unimedic Pharma Ab
Slovakia · Syntostigmin

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/c6ddbeb1-9df5-46af-b297-9992d09a16ed
GET /v1/drugs/c6ddbeb1-9df5-46af-b297-9992d09a16ed?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "unii": {
    "unii": "98IMH7M386",
    "rxcui": "7316",
    "inchikey": "OSZNNLWOYWAHSS-UHFFFAOYSA-M",
    "display_name": "NEOSTIGMINE METHYLSULFATE",
    "substance_type": "chemical",
    "ingredient_type": "INGREDIENT SUBSTANCE"
  },
  "route": "INTRAVENOUS",
  "spl_meta": {
    "7a9d996f-aecb-455f-95fc-1010e461d75d": {
      "match": "brand_token",
      "title": "NEOSTIGMINE METHYLSULFATE INJECTION [HIKMA PHARMACEUTICALS USA INC.]",
      "spl_version": "12",
      "published_date": "2026-03-20"
    }
  },
  "productid": "23155-517_fe40568f-ed8b-43fe-987f-839427a5924f",
  "productndc": "23155-517",
  "dosage_form": "INJECTION",
  "orange_book": {
    "appl_no": "208230",
    "products": [
      {
        "rs": false,
        "rld": false,
        "te_code": "AP",
        "strength": "5MG/10ML (0.5MG/ML)",
        "product_no": "001",
        "approval_date": "Nov 25, 2022"
      },
      {
        "rs": false,
        "rld": false,
        "te_code": "AP",
        "strength": "10MG/10ML (1MG/ML)",
        "product_no": "002",
        "approval_date": "Nov 25, 2022"
      }
    ],
    "appl_type": "A"
  },
  "dea_schedule": null,
  "product_type": "HUMAN PRESCRIPTION DRUG",
  "substance_name": "NEOSTIGMINE METHYLSULFATE",
  "shortage_reason": "Neostigmine Methylsulfate Injection",
  "shortage_status": "current",
  "proprietary_name": "Neostigmine Methylsulfate",
  "active_ingred_unit": "mg/mL",
  "application_number": "ANDA208230",
  "marketing_category": "ANDA",
  "nonproprietary_name": "Neostigmine Methylsulfate",
  "start_marketing_date": "20221125",
  "active_numerator_strength": ".5"
}

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