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United States· US:21922-090_5390c5ff-21e0-4b69-9e88-5593dbcbd9fe

Estradiol Gel

A estradiol product containing estradiol, registered in United States by Encube Ethicals, Inc..

ATC D11AX34US label

Checked against FDA National Drug Code directory (United States) on

Informational only — not a medical device.

SOURCE REGISTER · USFDA National Drug Code directory (Unite…normalisedEstradiol GelATCD11AX34REGISTER NO.US:21922-090_5390c5ff…PACKS LISTED2CHECKEDSeptember 27, 2026
Compare price across countriesPer daily dose · free accountAsk the assistant about estradiolAnswers with sources · free accountCheck interactionsSeverity free · mechanism on Growth

The record

At a glance

FDA National Drug Code directory (United States)
Active substance
ESTRADIOL
Manufacturer
Encube Ethicals, Inc.
Country
United States (US)
ATC code
D11AX34
ATC class
Estradiol
Reimbursed
Not published by this register
Source register
FDA National Drug Code directory (United States)
Last checked
September 27, 2026

Packs & prices · 2

  • ndc11
    2192209052
    30 PACKET in 1 CARTON (21922-090-52) / 1.25 g in 1 PACKET
  • ndc11
    21922-090-52

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

146 interactions on record for estradiol.

Graded by severity as the source publishes them — 7 severe. Severity grades are free for everyone; mechanism and management come with Growth.

  • Severity for every pair — free, no plan needed
  • The source, licence and sync date on every record
  • Mechanism and what to do for each pair — Growth plan
Check estradiol against other medicinesHow interaction checks work

Estradiol · interactions on record

146 records

  • 7 severe
  • 137 moderate
  • 2 minor

Most severe, free to view

  • Tranexamic acidB02AA02severe
  • HeminB06AB01severe
  • CarfilzomibL01XG02severe
  • CarfilzomibL01XX45severe
  • Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Mechanism and what to do, in the interaction check
Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Estradiol in 17 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All estradiol products

Authorised across Europe · EMA

The same active substance is authorised in 30 EEA countries. Names it is sold under:

  • Austria · Estrofem, Femseven
  • Belgium · Estradiol Besins, Estrofem
  • Bulgaria · Естрогел, Естрофем
  • Cyprus · Vagifem
  • Czechia · Estradiol Besins, Estrofem
  • Germany · Estradiol Fem Jenapharm, Estrifam
  • Denmark · Divigel, Ercostrol
  • Estonia · Divigel, Estradiol Besins
  • Spain · Divigel, Estradiol Besins
  • Finland · Divigel, Estradot
  • France · Dermestril, Dermestril Septem
  • United Kingdom (Northern Ireland) · Elleste, Elleste Solo Mx
  • Greece · Vagifem
  • Croatia · Estradiol Besins, Estrofem
  • Hungary · Estradiol Besins, Estrofem
  • Ireland · Divigel, Estradiol Sun
  • Iceland · Estring, Estrofem
  • Italy · Dermestril, Femseven
  • Lithuania · Divigel, Estradiol Besins
  • Luxembourg · Dermestril 100, Dermestril 25
  • Latvia · Estradiol Besins, Estrofem
  • Malta · Oestrogel Pump-Pack, Vagifem
  • Netherlands · Cetura, Estradiol Sandoz
  • Norway · Estradot, Estrogel
  • Poland · Divigel, Estrofem
  • Portugal · Dermestril, Estradot
  • Romania · Estradiol Besins
  • Sweden · Divigel, Estradiol Besins
  • Slovenia · Estradiol Besins, Vagifem
  • Slovakia · Estradiol Besins, Estrofem

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload
GET /v1/drugs/c23299de-11b5-44e8-8722-810f9d781ea2
GET /v1/drugs/c23299de-11b5-44e8-8722-810f9d781ea2?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "route": "TOPICAL",
  "source": "ndc",
  "strength": "1.25",
  "substance": "ESTRADIOL",
  "productndc": "21922-090",
  "dosage_form": "GEL",
  "dea_schedule": null,
  "strength_unit": "mg/1.25g",
  "application_number": "ANDA218507",
  "marketing_category": "ANDA"
}
API referenceMCP serverPlans

See everything about estradiol.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it freeOpen in the console