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United States· US:59651-548_9a7792f8-0b47-4a21-94af-0e470c343a9f

Metformin Hydrochloride

A metformin product containing metformin hydrochloride, registered in United States by Aurobindo Pharma Limited. The same ATC class is registered in 19 of our 19 countries.

ATC A10BA02Orange BookUS label

Checked against FDA National Drug Code directory (United States) on

Informational only — not a medical device.

SOURCE REGISTER · USFDA National Drug Code directory (Unite…normalisedMetformin HydrochlorideATCA10BA02REGISTER NO.US:59651-548_9a7792f8…PACKS LISTED3CHECKEDSeptember 12, 2026

Where it is registered

Metformin is registered in 19 of 19 countries.

Countries holding a registration under ATC A10BA02 (metformin), each read from that country’s own register.

  • This record: United States, from FDA National Drug Code directory (United States)
  • 11 of them publish a price we can compare per daily dose

Metformin · ATC A10BA02

19 / 19 countries

  • Belgiumprice
  • Canada
  • Czechiaprice
  • Denmark
  • Finlandprice
  • Franceprice
  • Germany
  • Icelandprice
  • Ireland
  • Italyprice
  • Japan
  • Netherlands
  • Norwayprice
  • Polandprice
  • Spainprice
  • Sweden
  • Switzerlandprice
  • United Kingdom
  • United Statesprice
Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of metformin costs, country by country.

Normalised to the WHO defined daily dose (2 g), the median price runs from $0.10 in Spain to $0.52 in Switzerland — a ×5.0 gap.

  • United States: $0.11 per daily dose (median across products in the class)
  • Public list prices, converted to USD at the rate date shown
  • US figures are pharmacy acquisition cost (CMS NADAC), not retail

Metformin · price per daily dose (2 g)

USD · FX 28 Sept 2026

  • CH Switzerland$0.52
  • CZ Czechia$0.24
  • IT Italy$0.19
  • FR France$0.17
  • US United States$0.11 (acquisition cost)
  • ES Spain$0.10
Median listed price per WHO defined daily dose, in each market that publishes a price. US = pharmacy acquisition cost (CMS NADAC), not a retail price. Open the full comparison

The record

At a glance

FDA National Drug Code directory (United States)
Active substance
Metformin Hydrochloride
Manufacturer
Aurobindo Pharma Limited
Country
United States (US)
ATC code
A10BA02
ATC class
Metformin
Defined daily dose
2 g, O
Reimbursed
Not published by this register
Source register
FDA National Drug Code directory (United States)
Last checked
September 12, 2026

Packs & prices · 3

  • ndc11
    5965154801
    100 TABLET, EXTENDED RELEASE in 1 BOTTLE (59651-548-01)
  • ndc11
    5965154805
    500 TABLET, EXTENDED RELEASE in 1 BOTTLE (59651-548-05)
  • ndc11
    5965154899
    1000 TABLET, EXTENDED RELEASE in 1 BOTTLE (59651-548-99)

Regulatory notes

UNII (FDA substance ID)
786Z46389E
METFORMIN HYDROCHLORIDE
RxCUI 235743
Orange Book
A079118
AB1AB
DailyMed SPL labels
1 version tracked

Interactions

790 interactions on record for metformin.

Graded by severity as the source publishes them — 17 severe. Severity grades are free for everyone; mechanism and management come with Growth.

  • Severity for every pair — free, no plan needed
  • The source, licence and sync date on every record
  • Mechanism and what to do for each pair — Growth plan

Metformin · interactions on record

790 records

  • 17 severe
  • 353 moderate
  • 45 minor
  • 370 info

Most severe, free to view

  • EthanolB05XX04severe
  • IoxilanV08AB12severe
  • CimetidineA02BA01moderate
  • RanitidineA02BA02moderate

5 more interactions with mechanism and management, from a commercially licensed source.

Sign in to check
  • Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Mechanism and what to do, in the interaction check
Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Metformin in 16 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All metformin products

Authorised across Europe · EMA

The same active substance is authorised in 30 EEA countries. Names it is sold under:

  • Austria · Diabetex, Glucophage
  • Belgium · Metformax, Metformin Activase 1000 Mg
  • Bulgaria · Meglucon Xr, Metformin Interdos Pharma
  • Cyprus · Brotmin, Glucophage
  • Czechia · Brotmin, Glucomet
  • Germany · Glucophage, Juformin
  • Denmark · Forminet, Lyomet
  • Estonia · Brotmin, Diabufor Xr
  • Spain · Brotmin, Dianben
  • Finland · Forminet, Glucophage
  • France · Glimezit, Glucophage
  • United Kingdom (Northern Ireland) · Abiano, Axpinet
  • Greece · Glucoformin, Glucofree
  • Croatia · Aglurab, Belformin
  • Hungary · Adimet, Adimet Xr
  • Ireland · Glucophage, Metformin Accord
  • Iceland · Forminet, Glucophage
  • Italy · Glucophage, Glucophage Unidie
  • Lithuania · Brotmin, Metfogamma
  • Luxembourg · Glucophage, Metformax
  • Latvia · Brotmin, Glucient Sr
  • Malta · Brotmin, Glyformin
  • Netherlands · Glucient Sr, Glycofren
  • Norway · Forminet, Glucophage
  • Poland · Abmetfina Xr, Avamina
  • Portugal · Allmet, Glucophage
  • Romania · Brotmin, Glucophage
  • Sweden · Forminet, Glucophage
  • Slovenia · Aglurab, Glucophage
  • Slovakia · Glucophage, Glucophage Xr

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload
GET /v1/drugs/b61b8dd0-69ca-4c91-a7a4-717b31d044e2
GET /v1/drugs/b61b8dd0-69ca-4c91-a7a4-717b31d044e2?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "unii": {
    "unii": "786Z46389E",
    "rxcui": "235743",
    "inchikey": "OETHQSJEHLVLGH-UHFFFAOYSA-N",
    "display_name": "METFORMIN HYDROCHLORIDE",
    "substance_type": "chemical",
    "ingredient_type": "INGREDIENT SUBSTANCE"
  },
  "route": "ORAL",
  "livertox": {
    "summary": null,
    "livertox_id": null,
    "hepatotoxicity_score": 2
  },
  "spl_meta": {
    "1cb2b2be-595c-4e72-8d2c-c1edc7f85682": {
      "match": "brand_token",
      "title": "METFORMIN HYDROCHLORIDE TABLET, FILM COATED, EXTENDED RELEASE [GOLDEN STATE MEDICAL SUPPLY, INC.]",
      "spl_version": "9",
      "published_date": "2026-06-01"
    }
  },
  "productid": "59651-548_9a7792f8-0b47-4a21-94af-0e470c343a9f",
  "productndc": "59651-548",
  "dosage_form": "TABLET, EXTENDED RELEASE",
  "orange_book": {
    "appl_no": "079118",
    "products": [
      {
        "rs": false,
        "rld": false,
        "te_code": "AB1",
        "strength": "500MG",
        "product_no": "001",
        "approval_date": "Jul 20, 2012"
      },
      {
        "rs": false,
        "rld": false,
        "te_code": "AB",
        "strength": "750MG",
        "product_no": "002",
        "approval_date": "Jul 20, 2012"
      }
    ],
    "appl_type": "A"
  },
  "dea_schedule": null,
  "product_type": "HUMAN PRESCRIPTION DRUG",
  "substance_name": "METFORMIN HYDROCHLORIDE",
  "proprietary_name": "Metformin Hydrochloride",
  "active_ingred_unit": "mg/1",
  "application_number": "ANDA079118",
  "marketing_category": "ANDA",
  "nonproprietary_name": "Metformin Hydrochloride",
  "start_marketing_date": "20240415",
  "active_numerator_strength": "500"
}

See everything about metformin.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.