Netherlands· NL-457b8cc4db95

Actilyse 50 mg, poeder en oplosmiddel voor oplossing voor injectie en infusie

A alteplase product containing alteplase, registered in Netherlands by Originalis B.V.. The same ATC class is registered in 14 of our 19 countries.

ATC B01AD02

Checked against CBG-MEB (Netherlands) on September 29, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about alteplaseAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Alteplase is registered in 14 of 19 countries.

Countries holding a registration under ATC B01AD02 (alteplase), each read from that country’s own register.

This record: Netherlands, from CBG-MEB (Netherlands)
8 of them publish a price we can compare per daily dose

Search alteplase products by name

Alteplase · ATC B01AD02

14 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Germany
Icelandprice
Ireland
Netherlands
Norwayprice
Polandprice
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of alteplase costs, country by country.

Normalised to the WHO defined daily dose (0.1 g), so markets compare like for like.

1 market with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Alteplase · price per daily dose (0.1 g)

USD · FX 28 Sept 2026

FI Finland$2204.37

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

CBG-MEB (Netherlands)

Active substance: ALTEPLASE
Manufacturer: Originalis B.V.
Country: Netherlands (NL)
ATC code: B01AD02
ATC class: Alteplase
Defined daily dose: 0.1 g, P
Reimbursed: Not published by this register
Source register: CBG-MEB (Netherlands)
Last checked: September 29, 2026

Packs & prices · 1

cbg_meb_id
122903//12248

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

146 interactions on record for alteplase.

Graded by severity as the source publishes them — 49 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check alteplase against other medicines How interaction checks work

Alteplase · interactions on record

146 records

49 severe
97 moderate

Most severe, free to view

DicoumarolB01AA01severe
WarfarinB01AA03severe
HeparinB01AB01severe
DalteparinB01AB04severe

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Alteplase in 16 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All alteplase products

Authorised across Europe · EMA

The same active substance is authorised in 29 EEA countries. Names it is sold under:

Austria · Actilyse, Actilyse Cathflo
Belgium · Actilyse, Actilyse Cathflo
Bulgaria · Актилизе
Cyprus · Actilyse, Actilyse Cathflo
Czechia · Actilyse
Germany · Actilyse, Actilyse Cathflo
Denmark · Actilyse
Estonia · Actilyse
Spain · Actilyse
Finland · Actilyse
France · Actilyse
United Kingdom (Northern Ireland) · Actilyse, Actilyse Cathflo
Greece · Actilyse, Actilyse Cathflo
Croatia · Actilyse
Hungary · Actilyse
Ireland · Actilyse, Actilyse Cathflo
Iceland · Actilyse
Italy · Actilyse
Lithuania · Actilyse
Luxembourg · Actilyse, Actilyse Cathflo
Latvia · Actilyse
Malta · Actilyse
Norway · Actilyse
Poland · Actilyse 10, Actilyse 20
Portugal · Actilyse, Actilyse Cathflo
Romania · Actilyse
Sweden · Actilyse
Slovenia · Actilyse, Actilyse Cathflo
Slovakia · Actilyse

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/b49b31b1-bcf4-4f51-9cfb-9136b94dca4a
GET /v1/drugs/b49b31b1-bcf4-4f51-9cfb-9136b94dca4a?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Poeder en oplosmiddel voor oplossing voor injectie",
  "route": null,
  "soort": "RVG",
  "source": "cbg_meb",
  "smpc_url": "https://www.geneesmiddeleninformatiebank.nl/smpc/h12248_smpc.pdf",
  "strength": null,
  "atc_label": "Alteplase",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/rvg122903",
  "excipients": [
    "ARGININE, (L-)",
    "FOSFORZUUR (E 338)",
    "POLYSORBAAT 80 (E 433)",
    "WATER VOOR INJECTIE"
  ],
  "substances": [
    "ALTEPLASE"
  ],
  "leaflet_url": "https://www.geneesmiddeleninformatiebank.nl/bijsluiters/h122903.pdf",
  "authorised_at": "2018/05/23",
  "procedure_number": null,
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "122903//12248",
  "additional_monitoring": "N"
}

API reference MCP server Plans

See everything about alteplase.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it free Open in the console