United States· US:67544-739_81155b23-9294-4758-80c8-5e33c4024868
Hydrochlorothiazide
A hydrochlorothiazide product containing hydrochlorothiazide, registered in United States by Aphena Pharma Solutions - Tennessee, LLC. The same ATC class is registered in 16 of our 19 countries.
Checked against FDA National Drug Code directory (United States) on
Informational only — not a medical device.
Where it is registered
Hydrochlorothiazide is registered in 16 of 19 countries.
Countries holding a registration under ATC C03AA03 (hydrochlorothiazide), each read from that country’s own register.
- This record: United States, from FDA National Drug Code directory (United States)
- 9 of them publish a price we can compare per daily dose
Hydrochlorothiazide · ATC C03AA03
16 / 19 countries
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Franceprice
- Germany
- Icelandprice
- Italyprice
- Japan
- Netherlands
- Norwayprice
- Polandprice
- Sweden
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of hydrochlorothiazide costs, country by country.
Normalised to the WHO defined daily dose (25 mg), the median price runs from $0.048 in France to $0.21 in Switzerland — a ×4.4 gap.
- 3 markets with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
Hydrochlorothiazide · price per daily dose (25 mg)
USD · FX 28 Sept 2026
- CH Switzerland$0.21
- IT Italy$0.075
- FR France$0.048
The record
At a glance
FDA National Drug Code directory (United States)- Active substance
- HYDROCHLOROTHIAZIDE
- Manufacturer
- Aphena Pharma Solutions - Tennessee, LLC
- Country
- United States (US)
- ATC code
- C03AA03
- ATC class
- Hydrochlorothiazide
- Defined daily dose
- 25 mg, O
- Reimbursed
- Not published by this register
- Source register
- FDA National Drug Code directory (United States)
- Last checked
- September 27, 2026
Packs & prices · 2
- ndc1167544-739-60
- ndc11675447396090 CAPSULE, GELATIN COATED in 1 PACKAGE (67544-739-60)
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
490 interactions on record for hydrochlorothiazide.
Graded by severity as the source publishes them — 4 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Hydrochlorothiazide · interactions on record
490 records
- 4 severe
- 208 moderate
- 21 minor
- 169 info
Most severe, free to view
- CisaprideA03FA02severe
- DolasetronA04AA04severe
- Aminolevulinic acidL01XD04severe
- Arsenic trioxideL01XX27severe
88 more interactions with mechanism and management, from a commercially licensed source.
Sign in to check- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Hydrochlorothiazide in 14 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- BelgiumAccuretic 20 mg - 12.5 mgPfizer
- United KingdomHydrochlorothiazide 10mg/5ml oral solutionSpecial Order
- SpainDRINE 25 MG COMPRIMIDOSChiesi España S.A.U.
- CanadaAPO-HYDROCHLOROTHIAZIDEAPOTEX INC
- GermanyHct 089pharm089pharm Gmbh
- SwitzerlandEsidrex
- SwedenEsidrex 25 mg TablettLaboratoires Juvise Pharmaceuticals
- FranceESIDREX 25 mg, comprimé sécableLABORATOIRES JUVISE PHARMACEUTICALS
Authorised across Europe · EMA
The same active substance is authorised in 24 EEA countries. Names it is sold under:
- Austria · Hct G.L.
- Bulgaria · Hypodehydra, Дехидразид
- Cyprus · Didralin, Hydrochlorothiazide Remedica
- Czechia · Hydrochlorothiazid Léčiva
- Germany · Hct 089pharm, Hct 1 A Pharma
- Denmark · Hydrochlorothiazide Orifarm, Hydromed
- Estonia · Hypothiazid
- Spain · Drine, Esidrex
- Finland · Hydrex, Hydrex Semi
- France · Esidrex, Hydrochlorothiazide Arrow
- United Kingdom (Northern Ireland) · Hydrochlorothiazide Aspire Pharma
- Greece · Diuren, Losazide
- Hungary · Hypothiazid
- Iceland · Hydromed
- Italy · Esidrex, Idroclorotiazide Aurobindo
- Lithuania · Hypothiazid
- Latvia · Hypothiazid
- Netherlands · Hydrochloorthiazide 1a Pharma, Hydrochloorthiazide Aurobindo
- Norway · Esidrex, Hydrochlorothiazide Orifarm
- Poland · Hydrochlorothiazide Aurovitas, Hydrochlorothiazidum Polpharma
- Portugal · Hidroclorotiazida Bluefish, Hidroclorotiazida Generis
- Romania · Nefrix
- Sweden · Esidrex, Hydrochlorothiazide Bluefish
- Slovakia · Hydrochlorothiazid Léčiva
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/ade9c26c-13b7-4f1a-83f3-e511cdc221d2 GET /v1/drugs/ade9c26c-13b7-4f1a-83f3-e511cdc221d2?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"route": "ORAL",
"source": "ndc",
"strength": "12.5",
"substance": "HYDROCHLOROTHIAZIDE",
"productndc": "67544-739",
"dosage_form": "CAPSULE, GELATIN COATED",
"dea_schedule": null,
"strength_unit": "mg/1",
"application_number": "NDA020504",
"marketing_category": "NDA AUTHORIZED GENERIC"
}See everything about hydrochlorothiazide.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.