Ireland· IE-PA-EU/1/07/397/002-004
Siklos 100 mg film-coated tablet
A hydroxycarbamide product containing hydroxycarbamide, registered in Ireland by Theravia. The same ATC class is registered in 16 of our 19 countries.
Checked against HPRA (Ireland) on
Informational only — not a medical device.
Where it is registered
Hydroxycarbamide is registered in 16 of 19 countries.
Countries holding a registration under ATC L01XX05 (hydroxycarbamide), each read from that country’s own register.
- This record: Ireland, from HPRA (Ireland)
- 10 of them publish a price we can compare per daily dose
Hydroxycarbamide · ATC L01XX05
16 / 19 countries
- Belgiumprice
- Canada
- Czechiaprice
- Denmark
- Finlandprice
- Franceprice
- Germany
- Icelandprice
- Ireland
- Italyprice
- Netherlands
- Norwayprice
- Polandprice
- Switzerlandprice
- United Kingdom
- United Statesprice
Price per daily dose
What a daily dose of hydroxycarbamide costs, country by country.
Normalised to the WHO defined daily dose (1.4 g), the median price runs from $0.51 in United States to $16.83 in France — a ×33 gap.
- 4 markets with a comparable price for this class
- Public list prices, converted to USD at the rate date shown
- US figures are pharmacy acquisition cost (CMS NADAC), not retail
Hydroxycarbamide · price per daily dose (1.4 g)
USD · FX 28 Sept 2026
- FR France$16.83
- CH Switzerland$2.74
- IT Italy$1.13
- US United States$0.51 (acquisition cost)
The record
At a glance
HPRA (Ireland)- Active substance
- Hydroxycarbamide
- Manufacturer
- Theravia
- Country
- Ireland (IE)
- ATC code
- L01XX05
- ATC class
- Hydroxycarbamide
- Defined daily dose
- 1.4 g, O
- Reimbursed
- Not published by this register
- Source register
- HPRA (Ireland)
- Last checked
- September 28, 2026
Packs & prices · 1
- ie_pa_numberEU/1/07/397/002-004
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Interactions
333 interactions on record for hydroxycarbamide.
Graded by severity as the source publishes them — 31 severe. Severity grades are free for everyone; mechanism and management come with Growth.
- Severity for every pair — free, no plan needed
- The source, licence and sync date on every record
- Mechanism and what to do for each pair — Growth plan
Hydroxycarbamide · interactions on record
333 records
- 31 severe
- 101 moderate
- 15 minor
- 186 info
Most severe, free to view
- DidanosineJ05AF02severe
- CladribineL01BB04severe
- Talimogene laherparepvecL01XL02severe
- Talimogen laherparepvecL01XX51severe
- Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Same medicine, other countries
Hydroxycarbamide in 16 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- CzechiaSIKLOSTHERAVIA, Neuilly-sur-Seine
- SpainSIKLOS 100 MG COMPRIMIDOS RECUBIERTOS CON PELICULATheravia
- FinlandSiklosTheravia
- FranceSIKLOS 100 mg, comprimé pelliculé sécableTHERAVIA
- IcelandSiklosTheravia
- NetherlandsSiklos filmomhulde tabletten, 100 mgTheravia
- NorwaySiklosTheravia
- PolandSiklosTHERAVIA
Authorised across Europe · EMA
The same active substance is authorised in 30 EEA countries. Names it is sold under:
- Austria · Ardjaq, Hydroxycarbamid Devatis
- Belgium · Hydrea
- Bulgaria · Хидреа
- Cyprus · Hydreasyn
- Czechia · Litalir
- Germany · Ardjaq, Hydroxycarbamid 1 A Pharma
- Denmark · Hydroxyurea Medac, Oribamide
- Estonia · Hydrea
- Spain · Hidroxicarbamida Hikma, Hidroxicarbamida Medac
- Finland · Hydrea, Hydroxyurea Medac
- France · Hydrea, Hydroxycarbamide Arrow
- United Kingdom (Northern Ireland) · Hydrea, Hydroxycarbamide
- Greece · Hydreasyn
- Croatia · Litalir, Xybaid
- Hungary · Hydroxycarbamide Pharmacenter, Litalir
- Iceland · Hydroxyurea Medac, Siklos
- Italy · Idrossicarbamide Aurobindo, Onco Carbide
- Liechtenstein · Siklos
- Lithuania · Hydrea
- Luxembourg · Hydrea, Hydroxycarbamid Devatis
- Latvia · Hydrea
- Malta · Hydroxycarbamide Eugia
- Netherlands · Hydroxycarbamide Devatis, Hydroxycarbamide Eugia
- Norway · Hydroxyurea Medac, Oribamide
- Poland · Hydroxycarbamid Eugia, Hydroxycarbamid Teva
- Portugal · Hidroxicarbamida Generis, Hidroxicarbamida Hikma
- Romania · Hydrea
- Sweden · Hydrea, Hydroxyurea Medac
- Slovenia · Hidroksisečnina Aptapharma, Litalir
- Slovakia · Hydroxykarbamid Medac, Xybaid
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of HPRA (Ireland). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/ad2f948c-9974-4004-a86d-03be41a82cf5 GET /v1/drugs/ad2f948c-9974-4004-a86d-03be41a82cf5?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"form": "Film-coated tablet",
"routes": [
"Oral use"
],
"source": "hpra",
"atc_all": [
"L01XX",
"L01XX05"
],
"strength": null,
"pa_number": "EU/1/07/397/002-004",
"substances": [
"Hydroxycarbamide"
],
"legal_basis": "Full application (Article 8(3) of Directive No 2001/83/EC)",
"market_info": "Unknown",
"authorised_at": "28/02/2011",
"dispensing_status": "Product subject to prescription which may not be renewed (A)",
"registration_status": "AU",
"supply_legal_status": "Supply through pharmacies only",
"interchangeable_code": null
}See everything about hydroxycarbamide.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.