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Netherlands· NL-1a1177defaf5

Metoject PEN 17,5 mg=0,35 ml, oplossing voor injectie in een voorgevulde pen

A methotrexate product containing methotrexaat dinatrium, registered in Netherlands by Euro Registratie Collectief B.V.. The same ATC class is registered in 15 of our 19 countries.

ATC L04AX03

Checked against CBG-MEB (Netherlands) on

Informational only — not a medical device.

SOURCE REGISTER · NLCBG-MEB (Netherlands)normalisedMetoject PEN 17,5 mg=0,35 ml, oplossi…ATCL04AX03REGISTER NO.NL-1a1177defaf5PACKS LISTED1CHECKEDSeptember 29, 2026
Compare price across countriesPer daily dose · free accountAsk the assistant about methotrexaat dinatriumAnswers with sources · free accountCheck interactionsSeverity free · mechanism on Growth

Where it is registered

Methotrexate is registered in 15 of 19 countries.

Countries holding a registration under ATC L04AX03 (methotrexate), each read from that country’s own register.

  • This record: Netherlands, from CBG-MEB (Netherlands)
  • 9 of them publish a price we can compare per daily dose
Search methotrexate products by name

Methotrexate · ATC L04AX03

15 / 19 countries

  • Belgiumprice
  • Canada
  • Czechiaprice
  • Denmark
  • Finlandprice
  • Germany
  • Icelandprice
  • Ireland
  • Italyprice
  • Netherlands
  • Norwayprice
  • Polandprice
  • Switzerlandprice
  • United Kingdom
  • United Statesprice
Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of methotrexate costs, country by country.

Normalised to the WHO defined daily dose (2.5 mg), the median price runs from $0.16 in United States to $5.98 in Switzerland — a ×38 gap.

  • 3 markets with a comparable price for this class
  • Public list prices, converted to USD at the rate date shown
  • US figures are pharmacy acquisition cost (CMS NADAC), not retail
Open the full comparison — free accountDrug prices for market access

Methotrexate · price per daily dose (2.5 mg)

USD · FX 28 Sept 2026

  • CH Switzerland$5.98
  • IT Italy$0.20
  • US United States$0.16 (acquisition cost)
Median listed price per WHO defined daily dose, in each market that publishes a price. US = pharmacy acquisition cost (CMS NADAC), not a retail price. Open the full comparison

The record

At a glance

CBG-MEB (Netherlands)
Active substance
METHOTREXAAT DINATRIUM
Manufacturer
Euro Registratie Collectief B.V.
Country
Netherlands (NL)
ATC code
L04AX03
ATC class
Methotrexate
Defined daily dose
2.5 mg, O
Reimbursed
Not published by this register
Source register
CBG-MEB (Netherlands)
Last checked
September 29, 2026

Packs & prices · 1

  • cbg_meb_id
    128808//111966

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

929 interactions on record for methotrexate.

Graded by severity as the source publishes them — 107 severe. Severity grades are free for everyone; mechanism and management come with Growth.

  • Severity for every pair — free, no plan needed
  • The source, licence and sync date on every record
  • Mechanism and what to do for each pair — Growth plan
Check methotrexate against other medicinesHow interaction checks work

Methotrexate · interactions on record

929 records

  • 107 severe
  • 466 moderate
  • 17 minor
  • 309 info

Most severe, free to view

  • OmeprazoleA02BC01severe
  • PantoprazoleA02BC02severe
  • LansoprazoleA02BC03severe
  • RabeprazoleA02BC04severe

30 more interactions with mechanism and management, from a commercially licensed source.

Sign in to check
  • Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Mechanism and what to do, in the interaction check
Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Methotrexate in 17 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All methotrexate products

Authorised across Europe · EMA

The same active substance is authorised in 30 EEA countries. Names it is sold under:

  • Austria · Ebetrexat, Methofill
  • Belgium · Basitrin, Emthexate
  • Bulgaria · Ebetrexat, Инжексат
  • Cyprus · Injexate, Methotrexate Accord
  • Czechia · Foxiemo, Injexate
  • Germany · Lantarel, Lantarel Fs
  • Denmark · Ebetrex, Emthexate
  • Estonia · Ebetrex, Metex
  • Spain · Bertanel, Imeth
  • Finland · Ebetrex, Injexate
  • France · Imenor, Imeth
  • United Kingdom (Northern Ireland) · Ebetrex, Injexate
  • Greece · Methobion, Methotrexate Pfizer
  • Croatia · Ebetrexat, Methofill
  • Hungary · Ebetrexat, Methofill
  • Ireland · Methofill, Methotrexate Abcur
  • Iceland · Jylamvo, Methotrexat Ebewe
  • Italy · Afslamet, Immutrex
  • Liechtenstein · Jylamvo, Nordimet
  • Lithuania · Ebetrexat, Metex
  • Luxembourg · Emthexate, Emthexate Teva Pharma
  • Latvia · Ebetrex, Metex
  • Malta · Methotrexate Aspire Pharma (Malta)
  • Norway · Ebetrex, Jylamvo
  • Poland · Ebetrexat, Metex
  • Portugal · Fauldexato, Ledertrexato
  • Romania · Methotrexat Ebewe, Metorthrit
  • Sweden · Ebetrex, Injexate
  • Slovenia · Methofill, Metoject
  • Slovakia · Foxiemo, Injexate

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload
GET /v1/drugs/aabc4cdd-30b3-4a5d-acb2-524ee55b89b8
GET /v1/drugs/aabc4cdd-30b3-4a5d-acb2-524ee55b89b8?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Oplossing voor injectie",
  "route": "Subcutaan gebruik",
  "soort": "RVG",
  "source": "cbg_meb",
  "smpc_url": "https://www.geneesmiddeleninformatiebank.nl/smpc/h111966_smpc.pdf",
  "strength": null,
  "atc_label": "Methotrexate",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/rvg128808",
  "excipients": [
    "NATRIUMCHLORIDE",
    "NATRIUMHYDROXIDE (E 524)",
    "WATER VOOR INJECTIE",
    "ZOUTZUUR (E 507)"
  ],
  "substances": [
    "METHOTREXAAT DINATRIUM"
  ],
  "leaflet_url": "https://www.geneesmiddeleninformatiebank.nl/bijsluiters/h128808.pdf",
  "authorised_at": "2021/09/21",
  "procedure_number": null,
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "128808//111966",
  "additional_monitoring": "N"
}
API referenceMCP serverPlans

See everything about methotrexate.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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