Actoplus Met

{
  "unii": {
    "unii": "786Z46389E",
    "rxcui": "235743",
    "inchikey": "OETHQSJEHLVLGH-UHFFFAOYSA-N",
    "display_name": "METFORMIN HYDROCHLORIDE",
    "substance_type": "chemical",
    "ingredient_type": "INGREDIENT SUBSTANCE"
  },
  "route": "ORAL",
  "spl_meta": {
    "42e49120-6f3f-11db-9fe1-0800200c9a66": {
      "match": "brand_token",
      "title": "ACTOPLUS MET (PIOGLITAZONE AND METFORMIN HYDROCHLORIDE) TABLET, FILM COATED [TAKEDA PHARMACEUTICALS AMERICA, INC.]",
      "spl_version": "27",
      "published_date": "2025-04-07"
    }
  },
  "productid": "64764-158_271ff8ce-9ae5-4b65-8581-7ced42f47f2f",
  "productndc": "64764-158",
  "dosage_form": "TABLET, FILM COATED",
  "orange_book": {
    "appl_no": "021842",
    "products": [
      {
        "rs": false,
        "rld": true,
        "te_code": null,
        "strength": "500MG;EQ 15MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**",
        "product_no": "001",
        "approval_date": "Aug 29, 2005"
      },
      {
        "rs": true,
        "rld": true,
        "te_code": "AB",
        "strength": "850MG;EQ 15MG BASE",
        "product_no": "002",
        "approval_date": "Aug 29, 2005"
      }
    ],
    "appl_type": "N"
  },
  "dea_schedule": null,
  "product_type": "HUMAN PRESCRIPTION DRUG",
  "substance_name": "METFORMIN HYDROCHLORIDE; PIOGLITAZONE HYDROCHLORIDE",
  "proprietary_name": "Actoplus Met",
  "active_ingred_unit": "mg/1; mg/1",
  "application_number": "NDA021842",
  "marketing_category": "NDA",
  "nonproprietary_name": "pioglitazone and metformin hydrochloride",
  "start_marketing_date": "20050829",
  "active_numerator_strength": "850; 15"
}