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Italy· 034231062

COMTAN*100 cpr rivestite 200 mg flacone

A entacapone product containing entacapone, registered in Italy by ORION CORPORATION, on the national reimbursement list. The same ATC class is registered in 18 of our 19 countries.

Reimbursed in Italy (AIFA class A)ATC N04BX02

Checked against the register on

Informational only — not a medical device.

SOURCE REGISTER · ITPublic registernormalisedCOMTAN*100 cpr rivestite 200 mg flaco…ATCN04BX02REGISTER NO.034231062PACKS LISTED1CHECKEDJune 4, 2026
Compare price across countriesPer daily dose · free accountAsk the assistant about entacaponeAnswers with sources · free accountCheck interactionsSeverity free · mechanism on Growth

Where it is registered

Entacapone is registered in 18 of 19 countries.

Countries holding a registration under ATC N04BX02 (entacapone), each read from that country’s own register.

  • This record: Italy
  • 10 of them publish a price we can compare per daily dose
Search entacapone products by name

Entacapone · ATC N04BX02

18 / 19 countries

  • Belgiumprice
  • Canada
  • Czechiaprice
  • Denmark
  • Finlandprice
  • Franceprice
  • Germany
  • Icelandprice
  • Ireland
  • Italyprice
  • Japan
  • Netherlands
  • Norwayprice
  • Polandprice
  • Sweden
  • Switzerlandprice
  • United Kingdom
  • United Statesprice
Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of entacapone costs, country by country.

Normalised to the WHO defined daily dose (1 g), the median price runs from $1.87 in France to $6.60 in Switzerland — a ×3.5 gap.

  • Italy: $6.27 per daily dose (median across products in the class)
  • Public list prices, converted to USD at the rate date shown
Open the full comparison — free accountDrug prices for market access

Entacapone · price per daily dose (1 g)

USD · FX 28 Sept 2026

  • CH Switzerland$6.60
  • IT Italy$6.27
  • FR France$1.87
Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

Active substance
Entacapone
Manufacturer
ORION CORPORATION
Country
Italy (IT)
ATC code
N04BX02
ATC class
Entacapone
Defined daily dose
1 g, O
Reimbursed
Yes
Last checked
June 4, 2026

Packs & prices · 1

1 priced
  • aic
    034231062
    COMTAN*100 cpr rivestite 200 mg flacone
    EUR 110.22

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

110 interactions on record for entacapone.

Graded by severity as the source publishes them — 2 severe. Severity grades are free for everyone; mechanism and management come with Growth.

  • Severity for every pair — free, no plan needed
  • The source, licence and sync date on every record
  • Mechanism and what to do for each pair — Growth plan
Check entacapone against other medicinesHow interaction checks work

Entacapone · interactions on record

110 records

  • 2 severe
  • 61 moderate
  • 1 minor
  • 46 info

Most severe, free to view

  • ProcarbazineL01XB01severe
  • Methylthioninium chlorideV03AB17severe
  • EpinephrineA01AD01moderate
  • MetoclopramideA03FA01moderate
  • Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Mechanism and what to do, in the interaction check
Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Entacapone in 16 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All entacapone products

Authorised across Europe · EMA

The same active substance is authorised in 16 EEA countries. Names it is sold under:

  • Cyprus · Encapia
  • Germany · Entacapon Hec
  • Denmark · Entacapone Viatris
  • Spain · Entacapona Viatris, Medapia
  • Finland · Entacapone Orion Pharma
  • France · Entacapone Arrow, Entacapone Viatris
  • United Kingdom (Northern Ireland) · Entacapone, Entacapone Hec
  • Croatia · Entakapon Hec
  • Iceland · Comtan, Comtess
  • Liechtenstein · Comtan, Comtess
  • Lithuania · Medapia
  • Malta · Medapia
  • Netherlands · Encapia, Entacapone Unichem
  • Norway · Comtan, Comtess
  • Portugal · Entacapona Aurobindo, Medapia
  • Sweden · Entacapone Viatris

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of the issuing authority. This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload
GET /v1/drugs/a49f7bf4-0bdc-4615-90f7-e1549fbf63a1
GET /v1/drugs/a49f7bf4-0bdc-4615-90f7-e1549fbf63a1?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "price": 110.22,
  "source": "aifa",
  "currency": "EUR",
  "strength": "ENTACAPONE 200MG 100 UNITA' USO ORALE",
  "substance": "Entacapone",
  "equivalence_group": "KTA",
  "transparency_flag": null
}
API referenceMCP serverPlans

See everything about entacapone.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it freeOpen in the console