Netherlands· NL-ececb4919e65

Rapamune 0,5 mg omhulde tabletten

A sirolimus product containing sirolimus, registered in Netherlands by Pfizer Europe MA EEIG. The same ATC class is registered in 13 of our 19 countries.

ATC L04AH01

Checked against CBG-MEB (Netherlands) on September 29, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about sirolimusAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Sirolimus is registered in 13 of 19 countries.

Countries holding a registration under ATC L04AH01 (sirolimus), each read from that country’s own register.

This record: Netherlands, from CBG-MEB (Netherlands)
8 of them publish a price we can compare per daily dose

Search sirolimus products by name

Sirolimus · ATC L04AH01

13 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Germany
Icelandprice
Netherlands
Norwayprice
Polandprice
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of sirolimus costs, country by country.

Normalised to the WHO defined daily dose (3 mg), the median price runs from $11.20 in France to $18.00 in Switzerland — a ×1.6 gap.

3 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Sirolimus · price per daily dose (3 mg)

USD · FX 28 Sept 2026

CH Switzerland$18.00
ES Spain$15.35
FR France$11.20

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

CBG-MEB (Netherlands)

Active substance: SIROLIMUS
Manufacturer: Pfizer Europe MA EEIG
Country: Netherlands (NL)
ATC code: L04AH01
ATC class: Sirolimus
Defined daily dose: 3 mg, O
Reimbursed: Not published by this register
Source register: CBG-MEB (Netherlands)
Last checked: September 29, 2026

Packs & prices · 1

cbg_meb_id
EU/1/01/171

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

737 interactions on record for sirolimus.

Graded by severity as the source publishes them — 162 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check sirolimus against other medicines How interaction checks work

Sirolimus · interactions on record

737 records

162 severe
441 moderate
8 minor
126 info

Most severe, free to view

ClotrimazoleA01AB18severe
NeomycinA07AA01severe
StreptomycinA07AA04severe
Polymyxin BA07AA05severe

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Sirolimus in 16 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All sirolimus products

Authorised across Europe · EMA

The same active substance is authorised in 4 EEA countries. Names it is sold under:

Germany · Sirolimus Panacea Biotec
Iceland · Hyftor, Rapamune
Liechtenstein · Hyftor, Rapamune
Norway · Hyftor, Rapamune

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/a088e170-954a-463c-b9a2-1730015eb4f5
GET /v1/drugs/a088e170-954a-463c-b9a2-1730015eb4f5?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Omhulde tablet",
  "route": "Oraal gebruik",
  "soort": null,
  "source": "cbg_meb",
  "smpc_url": "https://www.ema.europa.eu/en/documents/product-information/rapamune-epar-product-information_nl.pdf",
  "strength": null,
  "atc_label": "Sirolimus",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/cp106109",
  "excipients": [
    "AMMONIA (E 527)",
    "CALCIUMSULFAAT 0-WATER (E 516)",
    "CARNAUBAWAS (E 903)",
    "CELLULOSE, MICROKRISTALLIJN (E 460(i))",
    "GLYCERYLMONO-OLEAAT",
    "IJZEROXIDE  BRUIN (E 172)",
    "IJZEROXIDE GEEL (E 172)",
    "IJZEROXIDE ROOD  (E 172)",
    "LACTOSE 1-WATER",
    "MACROGOL 20000",
    "MACROGOL 8000",
    "MAGNESIUMSTEARAAT (E 470b)",
    "POLOXAMEER 188",
    "POVIDON K 30 (E 1201)",
    "PROPYLEENGLYCOL (E 1520)",
    "RODE INKT",
    "SACCHAROSE",
    "SCHELLAK GLAZE, GEDEELTELIJK VERESTERD",
    "SCHELLAK GLAZE, GEDEELTELIJK VERESTERD",
    "SIMETICON",
    "TALK (E 553b)",
    "TITAANDIOXIDE (E 171)",
    "TOCOFEROL, DL-ALFA (E 307)"
  ],
  "substances": [
    "SIROLIMUS"
  ],
  "leaflet_url": null,
  "authorised_at": "2010/07/06",
  "procedure_number": "EMEA/H/C/000273",
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "EU/1/01/171",
  "additional_monitoring": "N"
}

API reference MCP server Plans

See everything about sirolimus.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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