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United States· US:47335-235_524f657e-d138-9c87-e063-6294a90a93ad

Methotrexate

A methotrexate product containing methotrexate sodium, registered in United States by Sun Pharmaceutical Industries, Inc.. The same ATC class is registered in 15 of our 19 countries.

ATC L04AX03

Checked against FDA National Drug Code directory (United States) on

Informational only — not a medical device.

SOURCE REGISTER · USFDA National Drug Code directory (Unite…normalisedMethotrexateATCL04AX03REGISTER NO.US:47335-235_524f657e…PACKS LISTED2CHECKEDSeptember 27, 2026
Compare price across countriesPer daily dose · free accountAsk the assistant about methotrexate sodiumAnswers with sources · free accountCheck interactionsSeverity free · mechanism on Growth

Where it is registered

Methotrexate is registered in 15 of 19 countries.

Countries holding a registration under ATC L04AX03 (methotrexate), each read from that country’s own register.

  • This record: United States, from FDA National Drug Code directory (United States)
  • 9 of them publish a price we can compare per daily dose
Search methotrexate products by name

Methotrexate · ATC L04AX03

15 / 19 countries

  • Belgiumprice
  • Canada
  • Czechiaprice
  • Denmark
  • Finlandprice
  • Germany
  • Icelandprice
  • Ireland
  • Italyprice
  • Netherlands
  • Norwayprice
  • Polandprice
  • Switzerlandprice
  • United Kingdom
  • United Statesprice
Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of methotrexate costs, country by country.

Normalised to the WHO defined daily dose (2.5 mg), the median price runs from $0.16 in United States to $5.98 in Switzerland — a ×38 gap.

  • United States: $0.16 per daily dose (median across products in the class)
  • Public list prices, converted to USD at the rate date shown
  • US figures are pharmacy acquisition cost (CMS NADAC), not retail
Open the full comparison — free accountDrug prices for market access

Methotrexate · price per daily dose (2.5 mg)

USD · FX 28 Sept 2026

  • CH Switzerland$5.98
  • IT Italy$0.20
  • US United States$0.16 (acquisition cost)
Median listed price per WHO defined daily dose, in each market that publishes a price. US = pharmacy acquisition cost (CMS NADAC), not a retail price. Open the full comparison

The record

At a glance

FDA National Drug Code directory (United States)
Active substance
METHOTREXATE SODIUM
Manufacturer
Sun Pharmaceutical Industries, Inc.
Country
United States (US)
ATC code
L04AX03
ATC class
Methotrexate
Defined daily dose
2.5 mg, O
Reimbursed
Not published by this register
Source register
FDA National Drug Code directory (United States)
Last checked
September 27, 2026

Packs & prices · 2

  • ndc11
    47335-235-83
  • ndc11
    47335-235-96

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

929 interactions on record for methotrexate.

Graded by severity as the source publishes them — 107 severe. Severity grades are free for everyone; mechanism and management come with Growth.

  • Severity for every pair — free, no plan needed
  • The source, licence and sync date on every record
  • Mechanism and what to do for each pair — Growth plan
Check methotrexate against other medicinesHow interaction checks work

Methotrexate · interactions on record

929 records

  • 107 severe
  • 466 moderate
  • 17 minor
  • 309 info

Most severe, free to view

  • OmeprazoleA02BC01severe
  • PantoprazoleA02BC02severe
  • LansoprazoleA02BC03severe
  • RabeprazoleA02BC04severe

30 more interactions with mechanism and management, from a commercially licensed source.

Sign in to check
  • Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Mechanism and what to do, in the interaction check
Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Methotrexate in 17 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All methotrexate products

Authorised across Europe · EMA

The same active substance is authorised in 31 EEA countries. Names it is sold under:

  • Austria · Ebetrexat, Methofill
  • Belgium · Basitrin, Emthexate
  • Bulgaria · Ebetrexat, Инжексат
  • Cyprus · Injexate, Methotrexate Accord
  • Czechia · Foxiemo, Injexate
  • Germany · Lantarel, Lantarel Fs
  • Denmark · Ebetrex, Emthexate
  • Estonia · Ebetrex, Metex
  • Spain · Bertanel, Imeth
  • Finland · Ebetrex, Injexate
  • France · Imenor, Imeth
  • United Kingdom (Northern Ireland) · Ebetrex, Injexate
  • Greece · Methobion, Methotrexate Pfizer
  • Croatia · Ebetrexat, Methofill
  • Hungary · Ebetrexat, Methofill
  • Ireland · Methofill, Methotrexate Abcur
  • Iceland · Jylamvo, Methotrexat Ebewe
  • Italy · Afslamet, Immutrex
  • Liechtenstein · Jylamvo, Nordimet
  • Lithuania · Ebetrexat, Metex
  • Luxembourg · Emthexate, Emthexate Teva Pharma
  • Latvia · Ebetrex, Metex
  • Malta · Methotrexate Aspire Pharma (Malta)
  • Netherlands · Basitrin, Ebetrex
  • Norway · Ebetrex, Jylamvo
  • Poland · Ebetrexat, Metex
  • Portugal · Fauldexato, Ledertrexato
  • Romania · Methotrexat Ebewe, Metorthrit
  • Sweden · Ebetrex, Injexate
  • Slovenia · Methofill, Metoject
  • Slovakia · Foxiemo, Injexate

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload
GET /v1/drugs/9dfd6f44-1f7d-442d-9491-cca4cb17a6de
GET /v1/drugs/9dfd6f44-1f7d-442d-9491-cca4cb17a6de?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "route": "ORAL",
  "source": "ndc",
  "strength": "2.5",
  "substance": "METHOTREXATE SODIUM",
  "productndc": "47335-235",
  "dosage_form": "TABLET",
  "dea_schedule": null,
  "strength_unit": "mg/1",
  "application_number": "ANDA201749",
  "marketing_category": "ANDA"
}
API referenceMCP serverPlans

See everything about methotrexate.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it freeOpen in the console