Netherlands· NL-ed7f27aaa1bc

Advagraf 3 mg, capsules met verlengde afgifte, hard

A tacrolimus product containing tacrolimus 0-water, registered in Netherlands by Astellas Pharma GmbH. The same ATC class is registered in 16 of our 19 countries.

ATC L04AD02

Checked against CBG-MEB (Netherlands) on September 29, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about tacrolimus 0-waterAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Tacrolimus is registered in 16 of 19 countries.

Countries holding a registration under ATC L04AD02 (tacrolimus), each read from that country’s own register.

This record: Netherlands, from CBG-MEB (Netherlands)
9 of them publish a price we can compare per daily dose

Search tacrolimus products by name

Tacrolimus · ATC L04AD02

16 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Germany
Icelandprice
Ireland
Italyprice
Japan
Netherlands
Norwayprice
Polandprice
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of tacrolimus costs, country by country.

Normalised to the WHO defined daily dose (5 mg), the median price runs from $0.77 in United States to $16.77 in Switzerland — a ×22 gap.

3 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown
US figures are pharmacy acquisition cost (CMS NADAC), not retail

Open the full comparison — free account Drug prices for market access

Tacrolimus · price per daily dose (5 mg)

USD · FX 28 Sept 2026

CH Switzerland$16.77
IT Italy$8.99
US United States$0.77 (acquisition cost)

Median listed price per WHO defined daily dose, in each market that publishes a price. US = pharmacy acquisition cost (CMS NADAC), not a retail price. Open the full comparison

The record

At a glance

CBG-MEB (Netherlands)

Active substance: TACROLIMUS 0-WATER
Manufacturer: Astellas Pharma GmbH
Country: Netherlands (NL)
ATC code: L04AD02
ATC class: Tacrolimus
Defined daily dose: 5 mg, O
Reimbursed: Not published by this register
Source register: CBG-MEB (Netherlands)
Last checked: September 29, 2026

Packs & prices · 1

cbg_meb_id
EU/1/07/387

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

1075 interactions on record for tacrolimus.

Graded by severity as the source publishes them — 238 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check tacrolimus against other medicines How interaction checks work

Tacrolimus · interactions on record

1075 records

238 severe
543 moderate
18 minor
217 info

Most severe, free to view

ClotrimazoleA01AB18severe
OmeprazoleA02BC01severe
LansoprazoleA02BC03severe
EsomeprazoleA02BC05severe

59 more interactions with mechanism and management, from a commercially licensed source.

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Tacrolimus in 16 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All tacrolimus products

Authorised across Europe · EMA

The same active substance is authorised in 30 EEA countries. Names it is sold under:

Austria · Adport, Dailiport
Belgium · Adoport, Dailiport
Bulgaria · Програф
Cyprus · Prograf, Tacrolimus Accord
Czechia · Dailiport, Gecrol
Germany · Crilomus, Dailiport
Denmark · Adport, Dailiport
Estonia · Dailiport, Lebsanan
Spain · Adoport, Cellmune
Finland · Adport, Adport,
France · Adoport, Conferoport
United Kingdom (Northern Ireland) · Adoport, Ascezo
Greece · Atodrit-Dermo, Eczatope Derm
Croatia · Atezyrix, Dermitopic
Hungary · Prograf, Tacrolimus Stada
Ireland · Prograf, Tacrolimus Accord
Iceland · Advagraf, Dailiport
Italy · Adoport, Carelimus
Liechtenstein · Advagraf, Envarsus
Lithuania · Dailiport, Lebsanan
Luxembourg · Prograft, Sumilor
Latvia · Dailiport, Lebsanan
Malta · Prograf
Norway · Adport, Advagraf
Poland · Cidimus, Dailiport
Portugal · Adoport, Dermitopic
Romania · Prograf, Tacrolimus Sandoz
Sweden · Adport, Adport,
Slovenia · Adoport, Dailiport
Slovakia · Atezyrix, Dailiport

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/92bd190a-fe23-4ff6-8bdd-feff23a3fa99
GET /v1/drugs/92bd190a-fe23-4ff6-8bdd-feff23a3fa99?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Capsule met verlengde afgifte, hard",
  "route": "Oraal gebruik",
  "soort": null,
  "source": "cbg_meb",
  "smpc_url": "https://www.ema.europa.eu/en/documents/product-information/advagraf-epar-product-information_nl.pdf",
  "strength": null,
  "atc_label": "Tacrolimus",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/cp102452",
  "excipients": [
    "ETHYLCELLULOSE (E 462)",
    "GELATINE (E 441)",
    "HYPROLOSE (E 463)",
    "HYPROMELLOSE (E 464)",
    "IJZEROXIDE GEEL (E 172)",
    "IJZEROXIDE ROOD  (E 172)",
    "IJZEROXIDE ROOD  (E 172)",
    "LACTOSE 1-WATER",
    "LECITHINE, SOYA (E 322)",
    "MAGNESIUMSTEARAAT (E 470b)",
    "NATRIUMLAURILSULFAAT",
    "RODE INKT",
    "SCHELLAK GLAZE, GEDEELTELIJK VERESTERD",
    "SIMETICON",
    "TITAANDIOXIDE (E 171)"
  ],
  "substances": [
    "TACROLIMUS 0-WATER"
  ],
  "leaflet_url": null,
  "authorised_at": "2009/04/27",
  "procedure_number": "EMEA/H/C/000712",
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "EU/1/07/387",
  "additional_monitoring": "N"
}

API reference MCP server Plans

See everything about tacrolimus.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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