Ireland· IE-PA-EU/1/25/1943/002
Alyftrek 125 mg/50 mg/10 mg film-coated tablets
A deutivacaftor, tezacaftor and vanzacaftor product containing vanzacaftor + tezacaftor + deutivacaftor, registered in Ireland by Vertex Pharmaceuticals (Ireland) Limited. The same ATC class is registered in 11 of our 19 countries.
Checked against HPRA (Ireland) on
Informational only — not a medical device.
Where it is registered
Deutivacaftor, tezacaftor and vanzacaftor is registered in 11 of 19 countries.
Countries holding a registration under ATC R07AX33 (deutivacaftor, tezacaftor and vanzacaftor), each read from that country’s own register.
- This record: Ireland, from HPRA (Ireland)
- 7 of them publish a price we can compare per daily dose
Deutivacaftor, tezacaftor and vanzacaftor · ATC R07AX33
11 / 19 countries
- Belgiumprice
- Czechiaprice
- Denmark
- Finlandprice
- Icelandprice
- Ireland
- Netherlands
- Norwayprice
- Switzerlandprice
- United Kingdom
- United Statesprice
The record
At a glance
HPRA (Ireland)- Active substance
- Vanzacaftor + TEZACAFTOR + Deutivacaftor
- Manufacturer
- Vertex Pharmaceuticals (Ireland) Limited
- Country
- Ireland (IE)
- ATC code
- R07AX33
- ATC class
- Deutivacaftor, tezacaftor and vanzacaftor
- Reimbursed
- Not published by this register
- Source register
- HPRA (Ireland)
- Last checked
- September 28, 2026
Packs & prices · 1
- ie_pa_numberEU/1/25/1943/002
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Same medicine, other countries
Deutivacaftor, tezacaftor and vanzacaftor in 10 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- United StatesALYFTREKVertex Pharmaceuticals Incorporated
- CzechiaALYFTREKVertex Pharmaceuticals (Ireland) Limited, Dublin
- FinlandAlyftrekVertex Pharmaceuticals (Ireland) Limited
- United KingdomAlyftrek 125mg/50mg/10mg tabletsVertex Pharmaceuticals (Europe) Ltd
- SwitzerlandAlyftrek
- NetherlandsAlyftrek 125 mg/50 mg/10 mg filmomhulde tablettenVertex Pharmaceuticals (Ireland) Limited
- NorwayAlyftrekVertex Pharmaceuticals (Ireland) Limited
- PolandAlyftrekVertex Pharmaceuticals (Ireland) Limited
Authorised across Europe · EMA
The same active substance is authorised in 3 EEA countries. Names it is sold under:
- Iceland · Alyftrek
- Liechtenstein · Alyftrek
- Norway · Alyftrek
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of HPRA (Ireland). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/75b54906-d76c-4498-ad00-fdc880e9df9d GET /v1/drugs/75b54906-d76c-4498-ad00-fdc880e9df9d?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"form": "Film-coated tablet",
"routes": [
"Oral use"
],
"source": "hpra",
"atc_all": [
"R07AX33"
],
"strength": null,
"pa_number": "EU/1/25/1943/002",
"substances": [
"Vanzacaftor",
"TEZACAFTOR",
"Deutivacaftor"
],
"legal_basis": "Full application (Article 8(3) of Directive No 2001/83/EC)",
"market_info": "Unknown",
"authorised_at": "30/06/2025",
"dispensing_status": "Product subject to prescription which may not be renewed (A)",
"registration_status": "AU",
"supply_legal_status": "Supply through pharmacies only",
"interchangeable_code": null
}See everything about deutivacaftor, tezacaftor and vanzacaftor.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.