Canada· CA-DIN-02467984

NAT-BOSENTAN

A bosentan product containing bosentan (bosentan monohydrate), registered in Canada by NATCO PHARMA (CANADA) INC. The same ATC class is registered in 18 of our 19 countries.

ATC C02KX01

Checked against Health Canada Drug Product Database (Canada) on October 1, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about bosentan (bosentan monohydrate)Answers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Bosentan is registered in 18 of 19 countries.

Countries holding a registration under ATC C02KX01 (bosentan), each read from that country’s own register.

This record: Canada, from Health Canada Drug Product Database (Canada)
11 of them publish a price we can compare per daily dose

Search bosentan products by name

Bosentan · ATC C02KX01

18 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Franceprice
Germany
Icelandprice
Ireland
Italyprice
Netherlands
Norwayprice
Polandprice
Spainprice
Sweden
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of bosentan costs, country by country.

Normalised to the WHO defined daily dose (0.25 g), the median price runs from $25.92 in Italy to $66.51 in Switzerland — a ×2.6 gap.

2 markets with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Bosentan · price per daily dose (0.25 g)

USD · FX 28 Sept 2026

CH Switzerland$66.51
IT Italy$25.92

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

Health Canada Drug Product Database (Canada)

Active substance: BOSENTAN (BOSENTAN MONOHYDRATE)
Manufacturer: NATCO PHARMA (CANADA) INC
Country: Canada (CA)
ATC code: C02KX01
ATC class: Bosentan
Defined daily dose: 0.25 g, O
Reimbursed: Not published by this register
Source register: Health Canada Drug Product Database (Canada)
Last checked: October 1, 2026

Packs & prices · 0

No packs listed by the register for this record.

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

355 interactions on record for bosentan.

Graded by severity as the source publishes them — 45 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check bosentan against other medicines How interaction checks work

Bosentan · interactions on record

355 records

45 severe
227 moderate
7 minor
69 info

Most severe, free to view

GlibenclamideA10BB01severe
Levonorgestrel and ethinylestradiolG03AA07severe
Desogestrel and ethinylestradiolG03AA09severe
Drospirenone and ethinylestradiolG03AA12severe

7 more interactions with mechanism and management, from a commercially licensed source.

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Bosentan in 16 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All bosentan products

Authorised across Europe · EMA

The same active substance is authorised in 30 EEA countries. Names it is sold under:

Austria · Bosentan Accord, Bosentan Reddy
Belgium · Bosentan Accord, Bosentan Sandoz
Bulgaria · Bosentan Sdz, Бозентан Акорд
Cyprus · Bactoced, Bosentan Accord
Czechia · Bosentan Abdi, Bosentan Accord
Germany · Bosentan 1 A Pharma, Bosentan Accord
Denmark · Bosentan Accord, Bosentan Cipla
Estonia · Bosentan Accord, Bosentan Norameda
Spain · Bosentan Accordpharma, Bosentán Accordpharma
Finland · Bosentan Accord
France · Bosentan Accord, Bosentan Arrow
United Kingdom (Northern Ireland) · Bosentan Accord, Bosentan Generics [uk]
Greece · Bocleer, Klimurtan
Croatia · Bosentan Cipla, Bosentan Makpharm
Hungary · Bosentan Pharmascience
Ireland · Bosentan Accord, Bosentan Zentiva
Iceland · Stayveer, Tracleer
Italy · Bosentan Abdi, Bosentan Accord
Liechtenstein · Stayveer, Tracleer
Lithuania · Bosentan Accord, Bosentan Norameda
Latvia · Bosentan Accord, Bosentan Norameda
Malta · Bosentan Aurobindo
Netherlands · Bosentan Abdi, Bosentan Accord
Norway · Bosentan Accord, Bosentan Cipla
Poland · Bopaho, Bosentan Accord
Portugal · Bosentano Accord, Bosentano Aurobindo
Romania · Bopaho, Bosentan Accord
Sweden · Bosentan Accord, Bosentan Sandoz
Slovenia · Bosentan Norameda
Slovakia · Bosentan Accord

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of Health Canada Drug Product Database (Canada). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/61d32b90-857b-4454-adcf-2b10507332bd
GET /v1/drugs/61d32b90-857b-4454-adcf-2b10507332bd?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "din": "02467984",
  "form": "TABLET",
  "class": "Human",
  "routes": [
    "ORAL"
  ],
  "source": "health_canada_dpd",
  "status": "MARKETED",
  "atc_raw": "C02KX01",
  "schedule": [
    "Prescription"
  ],
  "drug_code": "95635",
  "strengths": [
    "62.5 MG"
  ],
  "ahfs_class": null,
  "substances": [
    "BOSENTAN (BOSENTAN MONOHYDRATE)"
  ],
  "product_categorization": null
}

API reference MCP server Plans

See everything about bosentan.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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