United States· US:0280-1520_45267353-7d9d-4ce3-e063-6294a90a6fdc
Alka-Seltzer Plus Cold Sparkling Original
A medicinal product containing aspirin; phenylephrine bitartrate; chlorpheniramine maleate, registered in United States by Bayer HealthCare LLC..
Checked against FDA National Drug Code directory (United States) on
Informational only — not a medical device.
The record
At a glance
FDA National Drug Code directory (United States)- Active substance
- ASPIRIN; PHENYLEPHRINE BITARTRATE; CHLORPHENIRAMINE MALEATE
- Manufacturer
- Bayer HealthCare LLC.
- Country
- United States (US)
- ATC code
- —
- Reimbursed
- Not published by this register
- Source register
- FDA National Drug Code directory (United States)
- Last checked
- September 27, 2026
Packs & prices · 10
- ndc1102801520042 POUCH in 1 CARTON (0280-1520-04) / 2 TABLET, EFFERVESCENT in 1 POUCH
- ndc11028015202010 POUCH in 1 CARTON (0280-1520-20) / 2 TABLET, EFFERVESCENT in 1 POUCH
- ndc11028015203618 POUCH in 1 CARTON (0280-1520-36) / 2 TABLET, EFFERVESCENT in 1 POUCH
- ndc11028015204824 POUCH in 1 CARTON (0280-1520-48) / 2 TABLET, EFFERVESCENT in 1 POUCH
- ndc11028015207236 POUCH in 1 CARTON (0280-1520-72) / 2 TABLET, EFFERVESCENT in 1 POUCH
- ndc110280-1520-04
- ndc110280-1520-20
- ndc110280-1520-36
- ndc110280-1520-48
- ndc110280-1520-72
Regulatory notes
No shortage, Orange Book or US label notes for this record.
Same medicine, other countries
Aspirin; phenylephrine bitartrate; chlorpheniramine maleate in 2 other countries
What each register calls a product with the same active substance — salts and hydrates count as the same.
- SpainASPIRINA COMPLEX GRANULADO EFERVESCENTEBayer Hispania S.L.
- PolandPolopiryna ComplexZakłady Farmaceutyczne POLPHARMA S.A.
Authorised across Europe · EMA
The same active substance is authorised in 2 EEA countries. Names it is sold under:
- Spain · Aspirina Complex, Couldina
- Poland · Polopiryna Complex
Source: European Medicines Agency, Article 57 product data.
Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.
For developers
The same record over the API, and the raw payload
GET /v1/drugs/4cef8cf3-65d3-416f-8798-b2ad84a86094 GET /v1/drugs/4cef8cf3-65d3-416f-8798-b2ad84a86094?format=fhir
Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.
{
"route": "ORAL",
"source": "ndc",
"strength": "325; 7.8; 2",
"substance": "ASPIRIN; PHENYLEPHRINE BITARTRATE; CHLORPHENIRAMINE MALEATE",
"productndc": "0280-1520",
"dosage_form": "TABLET, EFFERVESCENT",
"dea_schedule": null,
"strength_unit": "mg/1; mg/1; mg/1",
"application_number": "M012",
"marketing_category": "OTC MONOGRAPH DRUG"
}See everything about aspirin; phenylephrine bitartrate; chlorpheniramine maleate.
This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.