United States· US:83368-075_7f954669-af25-4d50-8430-36dcc77fd78f

Ryzumvi

A phentolamine product containing phentolamine mesylate, registered in United States by Oyster Point Pharma, Inc.. The same ATC class is registered in 6 of our 19 countries.

ATC C04AB01Orange BookUS label

Checked against FDA National Drug Code directory (United States) on June 3, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about phentolamine mesylateAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Phentolamine is registered in 6 of 19 countries.

Countries holding a registration under ATC C04AB01 (phentolamine), each read from that country’s own register.

This record: United States, from FDA National Drug Code directory (United States)
2 of them publish a price we can compare per daily dose

Search phentolamine products by name

Phentolamine · ATC C04AB01

6 / 19 countries

Canada
Finlandprice
Japan
Netherlands
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

The record

At a glance

FDA National Drug Code directory (United States)

Active substance: phentolamine mesylate
Manufacturer: Oyster Point Pharma, Inc.
Country: United States (US)
ATC code: C04AB01
ATC class: Phentolamine
Defined daily dose: 10 mg, O
Reimbursed: Not published by this register
Source register: FDA National Drug Code directory (United States)
Last checked: June 3, 2026

Packs & prices · 2

ndc11
8336807530
6 POUCH in 1 CARTON (83368-075-30) / 5 VIAL, SINGLE-USE in 1 POUCH / .31 mL in 1 VIAL, SINGLE-USE
ndc11
8336807531
1 POUCH in 1 CARTON (83368-075-31) / 5 VIAL, SINGLE-USE in 1 POUCH / .31 mL in 1 VIAL, SINGLE-USE

Regulatory notes

UNII (FDA substance ID)

Y7543E5K9T

PHENTOLAMINE MESYLATE

RxCUI 227240

Orange Book

N217064

DailyMed SPL labels

1 version tracked

Interactions

182 interactions on record for phentolamine.

Graded by severity as the source publishes them — 1 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check phentolamine against other medicines How interaction checks work

Phentolamine · interactions on record

182 records

1 severe
167 moderate
14 minor

Most severe, free to view

TizanidineM03BX02severe
DimenhydrinatA04AB02moderate
ThiethylperazinA04AB03moderate
DiphenhydraminA04AB05moderate

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Phentolamine in 5 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All phentolamine products

Authorised across Europe · EMA

The same active substance is authorised in 5 EEA countries. Names it is sold under:

Spain · Oraverse
France · Oraverse
United Kingdom (Northern Ireland) · Phentolamine Mesilate Roma Pharmaceuticals
Italy · Oraverse
Netherlands · Regitine

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of FDA National Drug Code directory (United States). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/476a7335-9af7-490e-9e45-8d36d2c4cdf7
GET /v1/drugs/476a7335-9af7-490e-9e45-8d36d2c4cdf7?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "unii": {
    "unii": "Y7543E5K9T",
    "rxcui": "227240",
    "inchikey": "OGIYDFVHFQEFKQ-UHFFFAOYSA-N",
    "display_name": "PHENTOLAMINE MESYLATE",
    "substance_type": "chemical",
    "ingredient_type": "INGREDIENT SUBSTANCE"
  },
  "route": "OPHTHALMIC",
  "spl_meta": {
    "96bb1e53-c2cc-4e60-a21a-db0269c371bf": {
      "match": "brand_token",
      "title": "RYZUMVI (PHENTOLAMINE MESYLATE) SOLUTION/ DROPS [OYSTER POINT PHARMA, INC.]",
      "spl_version": "4",
      "published_date": "2024-11-25"
    }
  },
  "productid": "83368-075_7f954669-af25-4d50-8430-36dcc77fd78f",
  "productndc": "83368-075",
  "dosage_form": "SOLUTION/ DROPS",
  "orange_book": {
    "appl_no": "217064",
    "products": [
      {
        "rs": true,
        "rld": true,
        "te_code": null,
        "strength": "EQ 0.75% BASE",
        "product_no": "001",
        "approval_date": "Sep 25, 2023"
      }
    ],
    "appl_type": "N"
  },
  "dea_schedule": null,
  "product_type": "HUMAN PRESCRIPTION DRUG",
  "substance_name": "PHENTOLAMINE MESYLATE",
  "proprietary_name": "Ryzumvi",
  "active_ingred_unit": "mg/mL",
  "application_number": "NDA217064",
  "marketing_category": "NDA",
  "nonproprietary_name": "phentolamine mesylate",
  "start_marketing_date": "20240325",
  "active_numerator_strength": "10"
}

API reference MCP server Plans

See everything about phentolamine.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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