Netherlands· NL-05a9f5980964

Constella 290 microgram harde capsules

A linaclotide product containing linaclotide, registered in Netherlands by AbbVie Deutschland GmbH & Co. KG. The same ATC class is registered in 14 of our 19 countries.

ATC A06AX04

Checked against CBG-MEB (Netherlands) on September 29, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about linaclotideAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Linaclotide is registered in 14 of 19 countries.

Countries holding a registration under ATC A06AX04 (linaclotide), each read from that country’s own register.

This record: Netherlands, from CBG-MEB (Netherlands)
8 of them publish a price we can compare per daily dose

Search linaclotide products by name

Linaclotide · ATC A06AX04

14 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Icelandprice
Ireland
Japan
Netherlands
Norwayprice
Polandprice
Switzerlandprice
United Kingdom
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of linaclotide costs, country by country.

Normalised to the WHO defined daily dose (0.29 mg), so markets compare like for like.

1 market with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Linaclotide · price per daily dose (0.29 mg)

USD · FX 28 Sept 2026

CH Switzerland$2.73

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

CBG-MEB (Netherlands)

Active substance: LINACLOTIDE
Manufacturer: AbbVie Deutschland GmbH & Co. KG
Country: Netherlands (NL)
ATC code: A06AX04
ATC class: Linaclotide
Defined daily dose: 0.29 mg, O
Reimbursed: Not published by this register
Source register: CBG-MEB (Netherlands)
Last checked: September 29, 2026

Packs & prices · 1

cbg_meb_id
EU/1/12/801

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

66 interactions on record for linaclotide.

Graded by severity as the source publishes them — 17 moderate. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check linaclotide against other medicines How interaction checks work

Linaclotide · interactions on record

66 records

17 moderate
49 minor

Most severe, free to view

IUP aus Plastik mit GestagenG02BA03moderate
Levonorgestrel and ethinylestradiolG03AA07moderate
Desogestrel and ethinylestradiolG03AA09moderate
Drospirenone and ethinylestradiolG03AA12moderate

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Linaclotide in 13 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All linaclotide products

Authorised across Europe · EMA

The same active substance is authorised in 4 EEA countries. Names it is sold under:

United Kingdom (Northern Ireland) · Constella
Iceland · Constella
Liechtenstein · Constella
Norway · Constella

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of CBG-MEB (Netherlands). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/3e921fc2-ab0b-436d-8bdc-76bf7ebe08b0
GET /v1/drugs/3e921fc2-ab0b-436d-8bdc-76bf7ebe08b0?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Capsule, hard",
  "route": "Oraal gebruik",
  "soort": null,
  "source": "cbg_meb",
  "smpc_url": "https://www.ema.europa.eu/en/documents/product-information/constella-epar-product-information_nl.pdf",
  "strength": null,
  "atc_label": "Linaclotide",
  "detail_url": "https://www.geneesmiddeleninformatiebank.nl/nl/cp110842",
  "excipients": [
    "AMMONIA (E 527)",
    "CALCIUMCHLORIDE 2-WATER (E 509)",
    "CELLULOSE, MICROKRISTALLIJN (E 460(i))",
    "GELATINE (E 441)",
    "GRIJZE INKT",
    "HYPROMELLOSE 2910 (3 - 15 mPa.s) (E 464)",
    "IJZEROXIDE GEEL (E 172)",
    "IJZEROXIDE ROOD  (E 172)",
    "IJZEROXIDE ZWART (E 172)",
    "KALIUMHYDROXIDE (E 525)",
    "LEUCINE, (L-) (E 641)",
    "MACROGOL",
    "PROPYLEENGLYCOL (E 1520)",
    "SCHELLAK (E 904)",
    "TITAANDIOXIDE (E 171)",
    "TITAANDIOXIDE (E 171)"
  ],
  "substances": [
    "LINACLOTIDE"
  ],
  "leaflet_url": null,
  "authorised_at": "2012/11/26",
  "procedure_number": "EMEA/H/C/002490",
  "dispensing_status": "Uitsluitend recept",
  "registration_number": "EU/1/12/801",
  "additional_monitoring": "N"
}

API reference MCP server Plans

See everything about linaclotide.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

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