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Ireland· IE-PA-PA2004/005/002

Prothromplex TOTAL 500 IU powder and solvent for solution for injection

A coagulation factor ix, ii, vii and x in combination product containing human coagulation factor ii + human coagulation factor vii + human coagulation factor ix + human coagulation factor x, registered in Ireland by Baxalta Innovations GmbH. The same ATC class is registered in 11 of our 19 countries.

ATC B02BD01

Checked against HPRA (Ireland) on

Informational only — not a medical device.

SOURCE REGISTER · IEHPRA (Ireland)normalisedProthromplex TOTAL 500 IU powder and …ATCB02BD01REGISTER NO.IE-PA-PA2004/005/002PACKS LISTED1CHECKEDSeptember 28, 2026

Where it is registered

Coagulation factor ix, ii, vii and x in combination is registered in 11 of 19 countries.

Countries holding a registration under ATC B02BD01 (coagulation factor ix, ii, vii and x in combination), each read from that country’s own register.

  • This record: Ireland, from HPRA (Ireland)
  • 7 of them publish a price we can compare per daily dose

Coagulation factor ix, ii, vii and x in combination · ATC B02BD01

11 / 19 countries

  • Belgiumprice
  • Canada
  • Czechiaprice
  • Denmark
  • Finlandprice
  • Icelandprice
  • Ireland
  • Netherlands
  • Norwayprice
  • Polandprice
  • Switzerlandprice
Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

The record

At a glance

HPRA (Ireland)
Active substance
Human coagulation factor ii + Human coagulation factor vii + Human coagulation factor ix + Human coagulation factor x
Manufacturer
Baxalta Innovations GmbH
Country
Ireland (IE)
ATC code
B02BD01
ATC class
Coagulation factor IX, II, VII and X in combination
Defined daily dose
1.6 TSD, E
Reimbursed
Not published by this register
Source register
HPRA (Ireland)
Last checked
September 28, 2026

Packs & prices · 1

  • ie_pa_number
    PA2004/005/002

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

3 interactions on record for coagulation factor ix, ii, vii and x in combination.

Graded by severity as the source publishes them — 2 severe. Severity grades are free for everyone; mechanism and management come with Growth.

  • Severity for every pair — free, no plan needed
  • The source, licence and sync date on every record
  • Mechanism and what to do for each pair — Growth plan

Coagulation factor ix, ii, vii and x in combination · interactions on record

3 records

  • 2 severe
  • 1 moderate

Most severe, free to view

  • CarfilzomibL01XG02severe
  • CarfilzomibL01XX45severe
  • PegvaliaseA16AB19moderate
  • Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.
Mechanism and what to do, in the interaction check
Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Coagulation factor ix, ii, vii and x in combination in 4 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All coagulation factor ix, ii, vii and x in combination products

Authorised across Europe · EMA

The same active substance is authorised in 23 EEA countries. Names it is sold under:

  • Austria · Prothromplex Total
  • Belgium · Prothromplex
  • Bulgaria · Протромплекс Тотал, Протромплекс Тотал Nf
  • Czechia · Prothromplex Total Nf
  • Germany · Prothromplex Nf
  • Denmark · Prothromplex
  • Estonia · Prothromplex Total
  • Spain · Prothromplex Total
  • United Kingdom (Northern Ireland) · Prothromplex Total
  • Greece · Prothromplex Total
  • Hungary · Prothromplex Total
  • Italy · Proplex
  • Lithuania · Prothromplex
  • Luxembourg · Prothromplex
  • Latvia · Prothromplex Total
  • Malta · Prothromplex Total
  • Netherlands · Prothromplex
  • Norway · Prothromplex
  • Poland · Prothromplex Total Nf
  • Portugal · Prothromplex
  • Romania · Prothromplex Total
  • Sweden · Prothromplex
  • Slovakia · Prothromplex Nf, Prothromplex Total Nf

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of HPRA (Ireland). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload
GET /v1/drugs/34f53117-bc60-4d48-9369-fc8476269768
GET /v1/drugs/34f53117-bc60-4d48-9369-fc8476269768?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Powder and solvent for solution for injection",
  "routes": [
    "Intravenous use"
  ],
  "source": "hpra",
  "atc_all": [
    "B02BD01"
  ],
  "strength": null,
  "pa_number": "PA2004/005/002",
  "substances": [
    "Human coagulation factor ii",
    "Human coagulation factor vii",
    "Human coagulation factor ix",
    "Human coagulation factor x",
    "Human Protein C"
  ],
  "legal_basis": "Full application (Article 8(3) of Directive No 2001/83/EC)",
  "market_info": "Marketed",
  "authorised_at": "09/06/2023",
  "dispensing_status": "Product subject to prescription which may not be renewed (A)",
  "registration_status": "AU",
  "supply_legal_status": "Supply through pharmacies only",
  "interchangeable_code": null
}

See everything about coagulation factor ix, ii, vii and x in combination.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.