Ireland· IE-PA-PA22668/008/001

Evorel 50 micrograms per 24 hours Transdermal Patch

A estradiol product containing estradiol hemihydrate, registered in Ireland by Theramex Ireland Limited. The same ATC class is registered in 13 of our 19 countries.

ATC G03CA03

Checked against HPRA (Ireland) on September 28, 2026

Informational only — not a medical device.

Compare price across countriesPer daily dose · free account Ask the assistant about estradiol hemihydrateAnswers with sources · free account Check interactionsSeverity free · mechanism on Growth

Where it is registered

Estradiol is registered in 13 of 19 countries.

Countries holding a registration under ATC G03CA03 (estradiol), each read from that country’s own register.

This record: Ireland, from HPRA (Ireland)
9 of them publish a price we can compare per daily dose

Search estradiol products by name

Estradiol · ATC G03CA03

13 / 19 countries

Belgiumprice
Canada
Czechiaprice
Denmark
Finlandprice
Icelandprice
Ireland
Italyprice
Netherlands
Norwayprice
Polandprice
Switzerlandprice
United Statesprice

Blue: a registration under this ATC code. The ringed marker is this record’s country. Markets marked price publish a price we can compare per daily dose.

Price per daily dose

What a daily dose of estradiol costs, country by country.

Normalised to the WHO defined daily dose (0.3 mg), so markets compare like for like.

1 market with a comparable price for this class
Public list prices, converted to USD at the rate date shown

Open the full comparison — free account Drug prices for market access

Estradiol · price per daily dose (0.3 mg)

USD · FX 28 Sept 2026

CH Switzerland$0.11

Median listed price per WHO defined daily dose, in each market that publishes a price. Open the full comparison

The record

At a glance

HPRA (Ireland)

Active substance: Estradiol hemihydrate
Manufacturer: Theramex Ireland Limited
Country: Ireland (IE)
ATC code: G03CA03
ATC class: Estradiol
Defined daily dose: 0.3 mg, N
Reimbursed: Not published by this register
Source register: HPRA (Ireland)
Last checked: September 28, 2026

Packs & prices · 1

ie_pa_number
PA22668/008/001

Regulatory notes

No shortage, Orange Book or US label notes for this record.

Interactions

328 interactions on record for estradiol.

Graded by severity as the source publishes them — 7 severe. Severity grades are free for everyone; mechanism and management come with Growth.

Severity for every pair — free, no plan needed
The source, licence and sync date on every record
Mechanism and what to do for each pair — Growth plan

Check estradiol against other medicines How interaction checks work

Estradiol · interactions on record

328 records

7 severe
177 moderate
3 minor
131 info

Most severe, free to view

Tranexamic acidB02AA02severe
HeminB06AB01severe
CarfilzomibL01XG02severe
CarfilzomibL01XX45severe

10 more interactions with mechanism and management, from a commercially licensed source.

Interaction severity from DDInter 2.0 (Xiong G. et al., Nucleic Acids Res.), licensed CC BY-NC 4.0 — free for non-commercial use only; not covered by the Drug Database commercial licence.

Mechanism and what to do, in the interaction check

Source: DDInter 2.0 · synced 29 Sept 2026. Grades as the source publishes them.

Same medicine, other countries

Estradiol in 9 other countries

What each register calls a product with the same active substance — salts and hydrates count as the same.

All estradiol products

Authorised across Europe · EMA

The same active substance is authorised in 29 EEA countries. Names it is sold under:

Austria · Estrogel, Linoladiol
Belgium · Dermestril, Dermestril 100
Bulgaria · Лензето, Линоладиол N
Czechia · Estrahexal, Lenzetto
Germany · Dermestril 25, Dermestril 50
Denmark · Lenzetto, Østradiol Dlf
Estonia · Lenzetto, Linoladiol N
Spain · Estraderm Matrix, Estring
Finland · Divigel, Estrena
France · Estreva, Estring
United Kingdom (Northern Ireland) · Elleste, Estraderm Mx
Greece · Lenzetto, Vagirux
Croatia · Lenzetto, Linoladiol
Hungary · Divigel, Lenzetto
Iceland · Estradiol Hexal, Femanest
Italy · Dermestril-Septem, Estraderm Mx
Liechtenstein · Rewellfem
Lithuania · Lenzetto, Linoladiol N
Luxembourg · Dermestril 25, Dermestril-Septem
Latvia · Lenzetto, Linoladiol N
Malta · Estradiol Sandoz, Fematab
Netherlands · Estradiol Sandoz, Lenzetto
Norway · Estradiol Hexal, Lenzetto
Poland · Estreva, Fem 7
Portugal · Dermestril-Septem, Estreva
Romania · Lenzetto
Sweden · Femanest, Lenzetto
Slovenia · Estrofem, Lenzetto
Slovakia · Lenzetto, Vagirux

Source: European Medicines Agency, Article 57 product data.

Sourced from a public register and reproduced with attribution. Drug Database is not affiliated with, endorsed by, or a partner of HPRA (Ireland). This is an informational data service and not a medical device — verify against the official source of record before any clinical decision.

For developers

The same record over the API, and the raw payload

GET /v1/drugs/06d8787a-2099-45c4-9ae2-9e057ba43a1b
GET /v1/drugs/06d8787a-2099-45c4-9ae2-9e057ba43a1b?format=fhir

Every response carries last_synced_at, so freshness is a field rather than a promise. Below is exactly what the ingestion wrote, before any presentation — the same JSON the API returns under payload.

{
  "form": "Transdermal patch",
  "routes": [
    "Transdermal use"
  ],
  "source": "hpra",
  "atc_all": [
    "G03CA",
    "G03CA03"
  ],
  "strength": null,
  "pa_number": "PA22668/008/001",
  "substances": [
    "Estradiol hemihydrate"
  ],
  "legal_basis": "Full application (Article 8(3) of Directive No 2001/83/EC)",
  "market_info": "Marketed",
  "authorised_at": null,
  "dispensing_status": "Product subject to prescription which may not be renewed (A)",
  "registration_status": "AU",
  "supply_legal_status": "Supply through pharmacies only",
  "interchangeable_code": null
}

API reference MCP server Plans

See everything about estradiol.

This page is the registration. A free account adds the label text as the regulator wrote it, what it costs per daily dose across the markets that publish a price, a feed of what changes in the registers, and an assistant that answers with its sources. Interaction severity is free; mechanism and management are on the Growth plan. No card, nothing to install.

Try it free Open in the console