Timolol Maleate

{
  "unii": {
    "unii": "P8Y54F701R",
    "rxcui": "42933",
    "inchikey": "WLRMANUAADYWEA-NWASOUNVSA-N",
    "display_name": "TIMOLOL MALEATE",
    "substance_type": "chemical",
    "ingredient_type": "INGREDIENT SUBSTANCE"
  },
  "route": "OPHTHALMIC",
  "spl_meta": {
    "e16c33fd-aa86-49ad-a767-c79ade4a62c7": {
      "match": "brand_token",
      "title": "TIMOLOL MALEATE SOLUTION/ DROPS [PACIFIC PHARMA, INC.]",
      "spl_version": "16",
      "published_date": "2026-05-25"
    }
  },
  "productid": "82260-813_2f8c4356-d1fe-ff3f-e063-6394a90a2832",
  "productndc": "82260-813",
  "dosage_form": "SOLUTION",
  "orange_book": {
    "appl_no": "018086",
    "products": [
      {
        "rs": false,
        "rld": true,
        "te_code": "AT1",
        "strength": "EQ 0.25% BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**",
        "product_no": "001",
        "approval_date": "Approved Prior to Jan 1, 1982"
      },
      {
        "rs": false,
        "rld": true,
        "te_code": "AT1",
        "strength": "EQ 0.5% BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**",
        "product_no": "002",
        "approval_date": "Approved Prior to Jan 1, 1982"
      }
    ],
    "appl_type": "N"
  },
  "dea_schedule": null,
  "product_type": "HUMAN PRESCRIPTION DRUG",
  "substance_name": "TIMOLOL MALEATE",
  "proprietary_name": "Timolol Maleate",
  "active_ingred_unit": "mg/mL",
  "application_number": "NDA018086",
  "marketing_category": "NDA AUTHORIZED GENERIC",
  "nonproprietary_name": "Timolol Maleate",
  "start_marketing_date": "20200601",
  "active_numerator_strength": "5"
}